Pharmacological Properties of Trichostatin A, Focusing on the Anticancer Potential: A Comprehensive Review

被引:50
作者
Bouyahya, Abdelhakim [1 ]
El Omari, Nasreddine [2 ]
Bakha, Mohamed [3 ]
Aanniz, Tarik [4 ]
El Menyiy, Naoual [5 ]
El Hachlafi, Naoufal [6 ]
El Baaboua, Aicha [7 ]
El-Shazly, Mohamed [8 ]
Alshahrani, Mohammed Merae [9 ]
Al Awadh, Ahmed Abdullah [9 ]
Lee, Learn-Han [10 ]
Benali, Taoufiq [11 ]
Mubarak, Mohammad S. [12 ]
机构
[1] Mohammed V Univ Rabat, Fac Sci, Dept Biol, Lab Human Pathol Biol, Rabat 10106, Morocco
[2] Mohammed V Univ Rabat, Fac Med & Pharm, Lab Histol Embryol & Cytogenet, Rabat 10100, Morocco
[3] Sultan Moulay Slimane Univ, Polydisciplinary Fac Beni Mellal, Unit Plant Biotechnol & Sustainable Dev Nat Resou, POB 592, Mghila 23000, Beni Mellal, Morocco
[4] Mohammed V Univ Rabat, Rabat Med & Pharm Sch, Med Biotechnol Lab, BP 6203, Rabat, Morocco
[5] Natl Agcy Med & Aromat Plants, Lab Pharmacol, Taounate 34025, Morocco
[6] Sidi Mohmed Ben Abdellah Univ, Sci & Technol Fac, Microbial Biotechnol & Bioact Mol Lab, Imouzzer Rd Fez, Fes 30050, Morocco
[7] Abdelmalek Essaadi Univ, Fac Sci, Dept Biol, Biotechnol & Appl Microbiol Team, Tetouan 93000, Morocco
[8] Ain Shams Univ, Fac Pharm, Dept Pharmacognosy, Cairo 11566, Egypt
[9] Najran Univ, Fac Appl Med Sci, Dept Clin Lab Sci, Najran 61441, Saudi Arabia
[10] Monash Univ Malaysia, Jeffrey Cheah Sch Med & Hlth Sci, Microbiome & Bioresource Res Strength MBRS, Novel Bacteria & Drug Discovery Res Grp NBDD, Bandar Sunway 47500, Malaysia
[11] Cadi Ayyad Univ, Polydisciplinary Fac Safi, Environm & Hlth Team, BP 4162, Sidi Bouzid, Morocco
[12] Univ Jordan, Dept Chem, Amma 11942, Jordan
关键词
Trichostatin A; pharmacological activity; anticancer action; molecular mechanisms; epidrug; HISTONE DEACETYLASE INHIBITOR; A-INDUCED APOPTOSIS; CELL-CYCLE ARREST; EPITHELIAL-MESENCHYMAL TRANSITION; BREAST-CANCER CELLS; ANTITUMOR-ACTIVITY; GENE-EXPRESSION; CARCINOMA-CELLS; DOWN-REGULATION; HDAC INHIBITOR;
D O I
10.3390/ph15101235
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Trichostatin A (TSA), a natural derivative of dienohydroxamic acid derived from a fungal metabolite, exhibits various biological activities. It exerts antidiabetic activity and reverses high glucose levels caused by the downregulation of brain-derived neurotrophic factor (BDNF) expression in Schwann cells, anti-inflammatory activity by suppressing the expression of various cytokines, and significant antioxidant activity by suppressing oxidative stress through multiple mechanisms. Most importantly, TSA exhibits potent inhibitory activity against different types of cancer through different pathways. The anticancer activity of TSA appeared in many in vitro and in vivo investigations that involved various cell lines and animal models. Indeed, TSA exhibits anticancer properties alone or in combination with other drugs used in chemotherapy. It induces sensitivity of some human cancers toward chemotherapeutical drugs. TSA also exhibits its action on epigenetic modulators involved in cell transformation, and therefore it is considered an epidrug candidate for cancer therapy. Accordingly, this work presents a comprehensive review of the most recent developments in utilizing this natural compound for the prevention, management, and treatment of various diseases, including cancer, along with the multiple mechanisms of action. In addition, this review summarizes the most recent and relevant literature that deals with the use of TSA as a therapeutic agent against various diseases, emphasizing its anticancer potential and the anticancer molecular mechanisms. Moreover, TSA has not been involved in toxicological effects on normal cells. Furthermore, this work highlights the potential utilization of TSA as a complementary or alternative medicine for preventing and treating cancer, alone or in combination with other anticancer drugs.
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页数:53
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共 235 条
[1]   Role of glycogen synthase kinase 3 beta (GSK3β) in mediating the cytotoxic effects of the histone deacetylase inhibitor trichostatin A (TSA) in MCF-7 breast cancer cells [J].
Alao, John P. ;
Stavropoulou, Alexandra V. ;
Lam, Eric W-F ;
Coombes, R. Charles .
MOLECULAR CANCER, 2006, 5 (1)
[2]   Histone deacetylase inhibitor trichostatin a represses estrogen receptor α-dependent transcription and promotes proteasomal degradation of cyclin D1 in human breast carcinoma cell lines [J].
Alao, JP ;
Lam, EWF ;
Ali, S ;
Buluwela, L ;
Bordogna, W ;
Lockey, P ;
Varshochi, R ;
Stavropoulou, AV ;
Coombes, RC ;
Vigushin, DM .
CLINICAL CANCER RESEARCH, 2004, 10 (23) :8094-8104
[3]   Bioactive Constituents and Toxicological Evaluation of Selected Antidiabetic Medicinal Plants of Saudi Arabia [J].
Alqahtani, Ali S. ;
Ullah, Riaz ;
Shahat, Abdelaaty A. .
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2022, 2022
[4]   Trichostatin A increases BDNF protein expression by improving XBP-1s/ATF6/GRP78 axis in Schwann cells of diabetic peripheral neuropathy [J].
An, Jiahui ;
Zhang, Xiang ;
Jia, Keqi ;
Zhang, Cuihong ;
Zhu, Lin ;
Cheng, Meijuan ;
Li, Fan ;
Zhao, Song ;
Hao, Jun .
BIOMEDICINE & PHARMACOTHERAPY, 2021, 133
[5]   Synergistic anticancer effects of cisplatin and histone deacetylase inhibitors (SAHA and TSA) on cholangiocarcinoma cell lines [J].
Asgar, Md. Ali ;
Senawong, Gulsiri ;
Sripa, Banchob ;
Senawong, Thanaset .
INTERNATIONAL JOURNAL OF ONCOLOGY, 2016, 48 (01) :409-420
[6]  
Aziee S, 2018, Journal of Biomedical and Clinical Sciences (JBCS), V3, P54
[7]  
Baek Sun-Yong, 2006, [Journal of Cancer Prevention, 대한암예방학회지], V11, P205
[8]   Trichostatin A increases the thermosensitivity of human glioblastoma A172 cells [J].
Baek, SY ;
Kim, SR ;
Bae, MK ;
Hwang, JW ;
Kim, JS ;
Choi, YH ;
Wee, HJ ;
Kim, BS ;
Kim, JB ;
Yoon, S ;
Bae, SK .
NEUROSCIENCE LETTERS, 2006, 396 (03) :230-234
[9]   In vitro and in vivo characterization of the antibacterial activity and membrane damage mechanism of quinic acid against Staphylococcus aureus [J].
Bai, Jinrong ;
Wu, Yanping ;
Wang, Xiaoyan ;
Liu, Xiaoyan ;
Zhong, Kai ;
Huang, Yina ;
Chen, Yiting ;
Gao, Hong .
JOURNAL OF FOOD SAFETY, 2018, 38 (01)
[10]   Histone deacetylase inhibitor trichostatin A and proteasome inhibitor PS-341 synergistically induce apoptosis in pancreatic cancer cells [J].
Bai, Jirong ;
Demirjian, Aram ;
Sui, Jianhua ;
Marasco, Wayne ;
Callery, Mark P. .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2006, 348 (04) :1245-1253