Increment of the FRET efficiency between carbon dots and photosensitizers for enhanced photodynamic therapy

被引：28
作者：
Yang, Kun [1 ]
Li, Fan [1 ]
Che, Wangyuan [1 ]
Hu, Xiao [1 ]
Liu, Changjun [1 ]
Tian, Feng [1 ]
机构：
[1] Acad Mil Med Sci, Inst Med Equipment, Tianjin 300161, Peoples R China
来源：
RSC ADVANCES | 2016年 / 6卷 / 103期
基金：
中国国家自然科学基金;
关键词：
CANCER-THERAPY; QUANTUM DOTS; SINGLET OXYGEN; GOLD NANORODS; NANOPARTICLES; DELIVERY; PROBES; ACID;
D O I：
10.1039/c6ra20412k
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Mg/N double-doped carbon dots (CDs) with a quantum yield up to 84.6% were synthesized by a one-step hydrothermal method, and the as-prepared CDs were then successfully used as carriers for an insoluble photosensitizer (chlorin e6, Ce6). Besides the high fluorescence quantum yield of the CDs, the short donor-acceptor distance and excessive acceptors per donor of the designed CDs-Ce6 system contributed to the high fluorescence resonance energy transfer (FRET) efficiency (up to 84%) and final enhanced photodynamic reaction. The CDs-Ce6 system showed excellent hydrophilicity and particularly tunable FRET efficiency. Its singlet oxygen (SO) quantum yield was double that of pure Ce6, and a significant photodynamic therapy (PDT) effect was proven on HepG2 cancer cells.
引用
收藏
页码：101447 / 101451
页数：5
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