Glycogen Synthase Kinase Is a Regulator of the Circadian Clock of Neurospora crassa

被引：16

作者：

Tataroglu, Oezguer ^{[1
]}

Lauinger, Linda ^{[1
]}

Sancar, Gencer ^{[1
]}

Jakob, Katharina ^{[1
]}

Brunner, Michael ^{[1
]}

Diernfellner, Axel C. R. ^{[1
]}

机构：

[1] Heidelberg Univ, Biochem Ctr, D-69120 Heidelberg, Germany

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2012年 / 287卷 / 44期

关键词：

WHITE-COLLAR COMPLEX; TRANSCRIPTION FACTOR; FREQUENCY DETERMINES; PROTEIN STABILITY; FEEDBACK LOOPS; PHOSPHORYLATION; REVEALS; PERIOD; LIGHT; DEGRADATION;

D O I：

10.1074/jbc.M112.396622

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Timekeeping by circadian clocks relies upon precise adjustment of expression levels of clock proteins. Here we identify glycogen synthase kinase (GSK) as a novel and critical component of the circadian clock of Neurospora crassa that regulates the abundance of its core transcription factor white collar complex (WCC) on a post-transcriptional level. We show that GSK specifically binds and phosphorylates both subunits of the WCC. Reduced expression of GSK promotes an increased accumulation of WC-1, the limiting factor of the WCC, causing an acceleration of the circadian clock and a shorter free-running period.

引用

页码：36936 / 36943

页数：8

共 41 条

[1] Quantitative Proteomics Reveals a Dynamic Interactome and Phase-Specific Phosphorylation in the Neurospora Circadian Clock
Baker, Christopher L.
Kettenbach, Arminja N.
Loros, Jennifer J.
Gerber, Scoff A.
Dunlap, Jay C.
[J]. MOLECULAR CELL, 2009, 34 (03) : 354 - 363
[2] The band mutation in Neurospora crassa is a dominant allele of ras-1 implicating RAS signaling in circadian output
Belden, William J.
Larrondo, Luis F.
Froehlich, Allan C.
Shi, Mi
Chen, Chen-Hui
Loros, Jennifer J.
Dunlap, Jay C.
[J]. GENES & DEVELOPMENT, 2007, 21 (12) : 1494 - 1505
[3] Interlocked feedback loops contribute to the robustness of the Neurospora circadian clock
Cheng, P
Yang, YH
Liu, Y
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (13) : 7408 - 7413
[4] A high-throughput gene knockout procedure for Neurospora reveals functions for multiple transcription factors
Colot, Hildur V.
Park, Gyungsoon
Turner, Gloria E.
Ringelberg, Carol
Crew, Christopher M.
Litvinkova, Liubov
Weiss, Richard L.
Borkovich, Katherine A.
Dunlap, Jay C.
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (27) : 10352 - 10357
[5] Phosphorylations: making the Neurospora crassa circadian clock tick
Diernfellner, A. C. R.
Schafmeier, T.
[J]. FEBS LETTERS, 2011, 585 (10) : 1461 - 1466
[6] Molecular mechanism of temperature sensing by the circadian clock of Neurospora crassa
Diernfellner, ACR
Schafmeier, T
Merrow, MW
Brunner, M
[J]. GENES & DEVELOPMENT, 2005, 19 (17) : 1968 - 1973
[7] Alternative initiation of translation and time-specific phosphorylation yield multiple forms of the essential clock protein FREQUENCY
Garceau, NY
Liu, Y
Loros, JJ
Dunlap, JC
[J]. CELL, 1997, 89 (03) : 469 - 476
[8] A PEST-like element in FREQUENCY determines the length of the circadian period in Neurospora crassa
Görl, M
Merrow, M
Huttner, B
Johnson, J
Roenneberg, T
Brunner, M
[J]. EMBO JOURNAL, 2001, 20 (24) : 7074 - 7084
[9] The Exosome Regulates Circadian Gene Expression in a Posttranscriptional Negative Feedback Loop
Guo, Jinhu
Cheng, Ping
Yuan, Haiyan
Liu, Yi
[J]. CELL, 2009, 138 (06) : 1236 - 1246
[10] FWD1-mediated degradation of FREQUENCY in Neurospora establishes a conserved mechanism for circadian clock regulation
He, Q
Cheng, P
Yang, YH
He, QY
Yu, HT
Liu, Y
[J]. EMBO JOURNAL, 2003, 22 (17) : 4421 - 4430

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