Antiangiogenic Polyketides from Peperomia dindygulensis Miq.

被引：27
作者：
Wang, Qi-Wei [2 ]
Yu, De-Hong [1 ]
Lin, Meng-Gan [2 ]
Zhao, Mei [3 ,4 ]
Zhu, Wen-Jun [2 ]
Lu, Qin [1 ]
Li, Gui-Xiu [5 ]
Wang, Chao [1 ]
Yang, Yi-Fang [2 ]
Qin, Xue-Mei [5 ]
Fang, Chao [1 ]
Chen, Hong-Zhuan [1 ]
Yang, Guo-Hong [2 ]
机构：
[1] Shanghai Jiao Tong Univ, Sch Med, Inst Med Sci, Dept Pharmacol, Shanghai 200025, Peoples R China
[2] Shanghai Inst Pharmaceut Ind, Dept Tradit Chinese Med, Shanghai 200040, Peoples R China
[3] Shanghai Inst Hlth Sci, Dept Pharm, Shanghai 201318, Peoples R China
[4] Shanghai Jiao Tong Univ, Sch Med, Hlth Sch, Dept Pharm, Shanghai 201318, Peoples R China
[5] Shanxi Univ, Sch Chem, Dept Pharmaceut Sci, Taiyuan 030006, Peoples R China
来源：
MOLECULES | 2012年 / 17卷 / 04期
基金：
中国国家自然科学基金;
关键词：
Peperomia dindygulensis Miq; polyketides; antiangiogenic activity; SECOLIGNANS; 2-ACYLCYCLOHEXANE-1,3-DIONE; LIGNANS;
D O I：
10.3390/molecules17044474
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Two new polyketides: 2Z-(heptadec-12-enyl)-4-hydroxy-3,4,7,8-tetrahydro-2H-chromen-5(6H)-one (1) and 2-(heptadec-12-enyl)-5-hydroxy-5,6,7,8-tetrahydrochromen-4-one (2), together with eleven known compounds: 4-hydroxy-2-[(3,4-methylenedioxy-phenyl)tridecanoyl] cyclohexane-1,3-dione (3), oleiferinone (4), 4-hydroxy-2-[(3,4-methylenedioxy-phenyl)undecanoyl] cyclohexane-1,3-dione (5), 4-hydroxy-2-[(11-phenylundecanoyl)cyclohexane-1,3-dione (6), proctorione C (7), surinone C (8), 5-hydroxy-7,8,4'-trimethoxyflavone (9), 5-hydroxy-7,8,3',4'-tetramethoxyflavone (10), 5-hydroxy-7,3',4'-trimethoxyflavone (11), 5,8-dihydroxy-7,3',4'-trimethoxyflavone (12) and cepharanone B (13) were isolated from the whole plant of Peperomia dindygulensis Miq. Their structures were elucidated by spectroscopic methods, including 2D-NMR techniques. Compounds 2, 3, 5 and 8 inhibited human umbilical vein endothelial cell (HUVEC) proliferation and compounds 5 and 8 sharply suppressed HUVEC tube formation.
引用
收藏
页码：4474 / 4483
页数：10
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