Adoptive Cell Therapy for Patients with Melanoma

被引:16
作者
Dudley, Mark E. [1 ]
机构
[1] NCI, Surg Branch, NIH, Bethesda, MD 20892 USA
来源
JOURNAL OF CANCER | 2011年 / 2卷
关键词
TIL; melanoma; NY-ESO-1; interleukin-2; lymphodepletion;
D O I
10.7150/jca.2.360
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Adoptive cell therapy can be an effective treatment for some patients with advanced cancer. This report summarizes clinical trial results from the Surgery Branch, NCI, investigating tumor infiltrating lymphocytes (TIL) and gene engineered peripheral blood T cells for the therapy of patients with melanoma and other solid tumors.
引用
收藏
页码:360 / 362
页数:3
相关论文
共 11 条
[1]  
BESSER MJ, 2010, CLIN CANC RES
[2]   Adoptive T cell therapy of cancer [J].
Brenner, Malcolm K. ;
Heslop, Helen E. .
CURRENT OPINION IN IMMUNOLOGY, 2010, 22 (02) :251-257
[3]  
Dudley M. E., 2010, CLIN CANC RES
[4]   Adoptive Cell Therapy for Patients With Metastatic Melanoma: Evaluation of Intensive Myeloablative Chemoradiation Preparative Regimens [J].
Dudley, Mark E. ;
Yang, James C. ;
Sherry, Richard ;
Hughes, Marybeth S. ;
Royal, Richard ;
Kammula, Udai ;
Robbins, Paul F. ;
Huang, JianPing ;
Citrin, Deborah E. ;
Leitman, Susan F. ;
Wunderlich, John ;
Restifo, Nicholas P. ;
Thomasian, Armen ;
Downey, Stephanie G. ;
Smith, Franz O. ;
Klapper, Jacob ;
Morton, Kathleen ;
Laurencot, Carolyn ;
White, Donald E. ;
Rosenberg, Steven A. .
JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (32) :5233-5239
[5]   Adoptive cell transfer therapy following non-myeloablative but lymphodepleting chemotherapy for the treatment of patients with refractory metastatic melanoma [J].
Dudley, ME ;
Wunderlich, JR ;
Yang, JC ;
Sherry, RM ;
Topalian, SL ;
Restifo, NP ;
Royal, RE ;
Kammula, U ;
White, DE ;
Mavroukakis, SA ;
Rogers, LJ ;
Gracia, GJ ;
Jones, SA ;
Mangiameli, DP ;
Pelletier, MM ;
Gea-Banacloche, J ;
Robinson, MR ;
Berman, DM ;
Filie, AC ;
Abati, A ;
Rosenberg, SA .
JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (10) :2346-2357
[6]  
Dudley ME, 2002, SCIENCE, V298, P850, DOI 10.1126/science.1076514
[7]   Adoptive Cell Therapy Genetic Modification to Redirect Effector Cell Specificity [J].
Morgan, Richard A. ;
Dudley, Mark E. ;
Rosenberg, Steven A. .
CANCER JOURNAL, 2010, 16 (04) :336-341
[8]   Tumor Regression in Patients With Metastatic Synovial Cell Sarcoma and Melanoma Using Genetically Engineered Lymphocytes Reactive With NY-ESO-1 [J].
Robbins, Paul F. ;
Morgan, Richard A. ;
Feldman, Steven A. ;
Yang, James C. ;
Sherry, Richard M. ;
Dudley, Mark E. ;
Wunderlich, John R. ;
Nahvi, Azam V. ;
Helman, Lee J. ;
Mackall, Crystal L. ;
Kammula, Udai S. ;
Hughes, Marybeth S. ;
Restifo, Nicholas P. ;
Raffeld, Mark ;
Lee, Chyi-Chia Richard ;
Levy, Catherine L. ;
Li, Yong F. ;
El-Gamil, Mona ;
Schwarz, Susan L. ;
Laurencot, Carolyn ;
Rosenberg, Steven A. .
JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (07) :917-924
[9]  
Rosenberg SA, 2011, CLIN CANC RES
[10]   Adoptive cell transfer: a clinical path to effective cancer immunotherapy [J].
Rosenberg, Steven A. ;
Restifo, Nicholas P. ;
Yang, James C. ;
Morgan, Richard A. ;
Dudley, Mark E. .
NATURE REVIEWS CANCER, 2008, 8 (04) :299-308