Progressive depletion of peripheral B lymphocytes in 4-1BB (CD137) ligand/I-Eα-transgenic mice

被引：54
作者：
Zhu, GF
Flies, DB
Tamada, K
Sun, YL
Rodriguez, M
Fu, YX
Chen, LP
机构：
[1] Mayo Clin, Mayo Grad Sch, Dept Immunol, Rochester, MN 55905 USA
[2] Mayo Clin, Mayo Med Sch, Dept Immunol, Rochester, MN 55905 USA
[3] Mayo Clin, Mayo Med Sch, Dept Neurol, Rochester, MN 55905 USA
[4] Mayo Clin, Mayo Grad Sch, Dept Neurol, Rochester, MN 55905 USA
[5] Univ Chicago, Dept Pathol, Chicago, IL 60637 USA
[6] Eastern Hosp Heptaobiliary Surg, Shanghai, Peoples R China
[7] Shanghai Int Canc Inst, Shanghai, Peoples R China
来源：
JOURNAL OF IMMUNOLOGY | 2001年 / 167卷 / 05期
关键词：
D O I：
10.4049/jimmunol.167.5.2671
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Interaction of 4-1BB (CD137) and its ligand (4-1BBL) is thought to positively regulate cell-mediated and humoral immune responses. We have prepared transgenic mouse strains that express 4-1BBL cDNA under the control of MHC class II I-E alpha promoter. The 4-1BBL-transgenic mice show progressive splenomegaly and selective depletion of B220(+) B cells accompanied with low levels of circulating IgG and defective humoral responses to Ag challenge. In addition, splenocytes from the transgenic mice fail to provide stimulation for allogeneic T cells in both lymphoproliferative and CTL responses in vitro, whereas their T cells remain functionally normal. Our results reveal unexpected functions of 4-1BBL in the regulation of humoral immune responses and Ag presentation.
引用
收藏
页码：2671 / 2676
页数：6
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