An amygdalar neural ensemble that encodes the unpleasantness of pain

被引：251

作者：

Corder, Gregory ^{[1
,2
,3
,4
,10
,11
]}

Ahanonu, Biafra ^{[5
,6
,7
]}

Grewe, Benjamin F. ^{[5
,7
,12
,13
]}

Wang, Dong ^{[1
]}

Schnitzer, Mark J. ^{[5
,6
,7
,8
]}

Scherrer, Gregory ^{[1
,2
,3
,4
,9
]}

机构：

[1] Stanford Univ, Sch Med, Dept Anesthesiol Perioperat & Pain Med, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Dept Mol & Cellular Physiol, Stanford, CA 94305 USA

[3] Stanford Univ, Sch Med, Dept Neurosurg, Stanford, CA 94305 USA

[4] Stanford Univ, Sch Med, Stanford Neurosci Inst, Stanford, CA 94305 USA

[5] Stanford Univ, Dept Biol, Stanford, CA 94305 USA

[6] Stanford Univ, Howard Hughes Med Inst, Stanford, CA 94305 USA

[7] Stanford Univ, CNC Program, Stanford, CA 94305 USA

[8] Stanford Univ, Dept Appl Phys, Stanford, CA 94305 USA

[9] Stanford Univ, New York Stem Cell Fdn Robertson Investigator, Stanford, CA 94305 USA

[10] Univ Penn, Dept Psychiat, Perelman Sch Med, Philadelphia, PA 19104 USA

[11] Univ Penn, Dept Neurosci, Perelman Sch Med, Philadelphia, PA 19104 USA

[12] ETH, Inst Neuroinformat, CH-8057 Zurich, Switzerland

[13] Univ Zurich, CH-8057 Zurich, Switzerland

来源：

SCIENCE | 2019年 / 363卷 / 6424期

基金：

瑞士国家科学基金会; 美国国家科学基金会; 美国国家卫生研究院;

关键词：

BASOLATERAL AMYGDALA; TACTILE ALLODYNIA; NEUROPATHIC PAIN; CIRCUITS; NEURONS; FEAR; REPRESENTATION; STIMULATION; INHIBITION; SENSATION;

D O I：

10.1126/science.aap8586

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Pain is an unpleasant experience. How the brain's affective neural circuits attribute this aversive quality to nociceptive information remains unknown. By means of time-lapse in vivo calcium imaging and neural activity manipulation in freely behaving mice encountering noxious stimuli, we identified a distinct neural ensemble in the basolateral amygdala that encodes the negative affective valence of pain. Silencing this nociceptive ensemble alleviated pain affective-motivational behaviors without altering the detection of noxious stimuli, withdrawal reflexes, anxiety, or reward. Following peripheral nerve injury, innocuous stimuli activated this nociceptive ensemble to drive dysfunctional perceptual changes associated with neuropathic pain, including pain aversion to light touch (allodynia). These results identify the amygdalar representations of noxious stimuli that are functionally required for the negative affective qualities of acute and chronic pain perception.

引用

页码：276 / +

页数：66

共 94 条

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Ahanonu B., 2018, CALCIUMLMAGINGANALYS, DOI [10.5281/zenodo.2222295, DOI 10.5281/ZENODO.2222295]

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