Apolipoprotein E4 accelerates dementia and increases cerebrospinal fluid tau levels in Alzheimer's disease

被引：46
|
作者：
Kanai, M
Shizuka, M
Urakami, K
Matsubara, E
Harigaya, Y
Okamoto, K
Shoji, M
机构：
[1] Gunma Univ, Sch Med, Dept Neurol, Maebashi, Gumma 3718511, Japan
[2] Tottori Univ, Fac Med, Div Neurol, Inst Neurol Sci, Yonago, Tottori 6838504, Japan
来源：
NEUROSCIENCE LETTERS | 1999年 / 267卷 / 01期
关键词：
Alzheimer's disease; apolipoprotein E4; cerebrospinal fluid; tau; A beta;
D O I：
10.1016/S0304-3940(99)00323-7
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
To examine the effect of apolipoprotein E (ApoE) 4 on the progression of Alzheimer's disease (AD), the clinical course of 33 AD patients (17 cases with ApoE epsilon 4 and 16 cases without ApoE epsilon 4) was evaluated with the mini-mental state examination (MMSE) and cerebrospinal fluid (CSF) biological markers. The decline of MMSE scores to zero was shortened in the ApoE4 group. During a mean follow-up of 20 months, a significant increase of CSF tau levels was observed in the ApoE4 group. A lower level of CSF A beta 1-42(43) was found in both the ApoE4 and non-ApoE4 groups than in age-matched normal controls. The ApoE epsilon 4 allele accelerates the progression of dementia and increases the levels of CSF tau in AD patients. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：65 / 68
页数：4
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