Cyclodextrin/poly(ethylene glycol) polypseudorotaxane hydrogels as a promising sustained-release system for lysozyme

被引：25

作者：

Higashi, Taishi ^{[1
]}

Tajima, Anna ^{[1
]}

Motoyama, Keiichi ^{[1
]}

Arima, Hidetoshi ^{[1
]}

机构：

[1] Kumamoto Univ, Grad Sch Pharmaceut Sci, Kumamoto 8620973, Japan

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 2012年 / 101卷 / 08期

关键词：

proteins; lysozyme; cyclodextrin; biomaterials; polypseudorotaxane; hydrogel; controlled release; sustained-release system; release mechanisms; CYCLODEXTRIN INCLUSION; POLY(ETHYLENE GLYCOL); PEGYLATED INSULIN; ORGANIC-COMPOUNDS; STARCHY MATERIALS; BLOCK-COPOLYMERS; PROTEIN RELEASE; SLOW-RELEASE; X-RAY; DRUG;

D O I：

10.1002/jps.23232

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In this study, to clarify the utility of polypseudorotaxane (PPRX) hydrogels composed of poly(ethylene glycol) (PEG) and a- or ?-cyclodextrin (a- or ?-CyD) as a sustained-release system for protein drugs, we prepared CyD PPRX hydrogels including lysozyme, and then the release profiles of lysozyme from these hydrogels and the release mechanisms were investigated. The a- and ?-CyD formed PPRX hydrogels by threading onto one PEG chain and two PEG chains, respectively. The formation of a- and ?-CyD PPRX hydrogels including lysozyme was based on physical cross-linking arisen from their columnar structures. The in vitro release rates of lysozyme were markedly decreased by the encapsulation into CyD PPRX hydrogels. In addition, when release data were plotted according to KorsmeyerPeppas model, the exponent values (n) in the a- and ?-CyD systems had no statistically significant difference, suggesting that these release mechanisms were almost same. In conclusion, these results suggest that a- and ?-CyD PPRX hydrogels possess the potential as a sustained-release system for lysozyme. (C) 2012 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 101:28912899, 2012

引用

页码：2891 / 2899

页数：9

共 37 条

[1] Potential use of γ-cyclodextrin polypseudorotaxane hydrogels as an injectable sustained release system for insulin [J].

Abu Hashim, Irhan Ibrahim ;

Higashi, Taishi ;

Anno, Takayuki ;

Motoyama, Keiichi ;

Abd-ElGawad, Abd-ElGawad Helmy ;

El-Shabouri, Mohamed H. ;

Borg, Thanaa Mohamed ;

Arima, Hidetoshi .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2010, 392 (1-2) :83-91

[2] Chitosan-based hydrogels for controlled, localized drug delivery [J].

Bhattarai, Narayan ;

Gunn, Jonathan ;

Zhang, Miqin .

ADVANCED DRUG DELIVERY REVIEWS, 2010, 62 (01) :83-99

[3] Prednisolone-α-cyclodextrin-star poly(ethylene glycol) polypseudorotaxane with delayed pH-sensitivity as a targeted drug delivery system [J].

Bilkova, Eliska ;

Sedlak, Milos ;

Imramovsky, Ales ;

Charova, Petra ;

Knotek, Petr ;

Benes, Ludvik .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2011, 414 (1-2) :42-47

[4] GRAFT-COPOLYMERS THAT EXHIBIT TEMPERATURE-INDUCED PHASE-TRANSITIONS OVER A WIDE-RANGE OF PH [J].

CHEN, GH ;

HOFFMAN, AS .

NATURE, 1995, 373 (6509) :49-52

[5] Mechanism and characteristics of protein release from lactitol-based cross-linked hydrogel [J].

Han, JH ;

Krochta, JM ;

Hsieh, YL ;

Kurth, MJ .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2000, 48 (11) :5658-5665

[6] COMPLEX-FORMATION BETWEEN POLY(ETHYLENE GLYCOL) AND ALPHA-CYCLODEXTRIN [J].

HARADA, A ;

KAMACHI, M .

MACROMOLECULES, 1990, 23 (10) :2821-2823

[7] THE MOLECULAR NECKLACE - A ROTAXANE CONTAINING MANY THREADED ALPHA-CYCLODEXTRINS [J].

HARADA, A ;

LI, J ;

KAMACHI, M .

NATURE, 1992, 356 (6367) :325-327

[8] Preparation and structures of supramolecules between cyclodextrins and polymers [J].

Harada, A .

COORDINATION CHEMISTRY REVIEWS, 1996, 148 :115-133

[9] DOUBLE-STRANDED INCLUSION COMPLEXES OF CYCLODEXTRIN THREADED ON POLY(ETHYLENE GLYCOL) [J].

HARADA, A ;

LI, J ;

KAMACHI, M .

NATURE, 1994, 370 (6485) :126-128

[10] Polymeric Rotaxanes [J].

Harada, Akira ;

Hashidzume, Akihito ;

Yamaguchi, Hiroyasu ;

Takashima, Yoshinori .

CHEMICAL REVIEWS, 2009, 109 (11) :5974-6023

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