Body mass index is associated with biological CSF markers of core brain pathology of Alzheimer's disease

被引：48

作者：

Ewers, Michael ^{[1
,2
]}

Schmitz, Susanne ^{[3
]}

Hansson, Oskar ^{[4
]}

Walsh, Cathal ^{[3
]}

Fitzpatrick, Annette ^{[5
]}

Bennett, David ^{[6
]}

Minthon, Lennart ^{[4
]}

Trojanowski, John Q. ^{[7
,8
]}

Shaw, Leslie M. ^{[7
,8
]}

Faluyi, Yetunde O. ^{[9
]}

Vellas, Bruno ^{[10
]}

Dubois, Bruno ^{[11
]}

Blennow, Kaj ^{[12
]}

Buerger, Katharina ^{[13
]}

Teipel, Stefan J. ^{[14
,15
]}

Weiner, Michael ^{[2
]}

Hampel, Harald ^{[16
]}

机构：

[1] Univ Calif San Francisco, Dept Radiol, VA Med Ctr, Ctr Neuroimaging Neurodegenerat Dis, San Francisco, CA 94121 USA

[2] Dept Vet Affairs Med Ctr, Ctr Imaging Neurodegenerat Dis, San Francisco, CA USA

[3] Trinity Coll Dublin, Dept Stat, Dublin, Ireland

[4] Lund Univ, Clin Memory Res Unit, Dept Clin Sci Malmo, Lund, Sweden

[5] Univ Washingtion, Dept Epidemiol, Seattle, WA USA

[6] Rush Univ, Rush Alzheimers Dis Ctr, Med Ctr, Chicago, IL 60612 USA

[7] Univ Penn, Sch Med, Inst Aging, Alzheimers Dis Core Ctr,Ctr Neurodegenerat Dis, Philadelphia, PA 19104 USA

[8] Univ Penn, Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

[9] Cambridgeshire & Peterborough Fdn NHS Trust, Liaison Psychiat Serv, Addenbrookes Hosp, Cambridge, England

[10] Univ Toulouse, Dept Geriatr Med, Toulouse, France

[11] Univ Paris 06, INSERM, U610, UPMC,UMRS 610,Salpetriere Hosp,AP HP, Paris, France

[12] Univ Goteborg, Clin Neurochem Lab, Dept Neurosci & Physiol, Sahlgrenska Univ Hosp, Molndal, Sweden

[13] Univ Munich, Inst Stroke & Dementia Res, Munich, Germany

[14] Univ Rostock, Dept Psychiat, Rostock, Germany

[15] German Ctr Neurodegenerat Disorders, DZNE, Rostock, Germany

[16] Goethe Univ Frankfurt, Dept Psychiat Psychosomat Med & Psychotherapy, Frankfurt, Germany

来源：

NEUROBIOLOGY OF AGING | 2012年 / 33卷 / 08期

基金：

美国国家卫生研究院;

关键词：

Alzheimer's disease; Body mass index; Cerebrospinal fluid; Tau protein; A beta(1-42); MILD COGNITIVE IMPAIRMENT; CEREBROSPINAL-FLUID; PHOSPHORYLATED-TAU; OLDER PERSONS; WEIGHT-LOSS; INCIDENT DEMENTIA; FOLLOW-UP; RISK; DIAGNOSIS; OBESITY;

D O I：

10.1016/j.neurobiolaging.2011.05.005

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Weight changes are common in aging and Alzheimer's disease (AD) and postmortem findings suggest a relation between lower body mass index (BMI) and increased AD brain pathology. In the current multicenter study, we tested whether lower BMI is associated with higher core AD brain pathology as assessed by cerebrospinal fluid (CSF)-based biological markers of AD in 751 living subjects: 308 patients with AD, 296 subjects with amnestic mild cognitive impairment (MCI), and 147 elderly healthy controls (HC). Based upon a priori cutoff values on CSF concentration of total tau and beta-amyloid (A beta(1-42)), subjects were binarized into a group with abnormal CSF biomarker signature (CSF+) and those without (CSF-). Results showed that BMI was significantly lower in the CSF+ when compared with the CSF- group (F = 27.7, df = 746, p < 0.001). There was no interaction between CSF signature and diagnosis or apolipoprotein E (ApoE) genotype. In conclusion, lower BMI is indicative of AD pathology as assessed with CSF-based biomarkers in demented and nondemented elderly subjects. Published by Elsevier Inc.

引用

页码：1599 / 1608

页数：10

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