Napyradiomycin Derivatives, Produced by a Marine-Derived Actinomycete, Illustrate Cytotoxicity by Induction of Apoptosis

被引：44

作者：

Farnaes, Lauge ^{[1
]}

Coufal, Nicole G. ^{[2
]}

Kauffman, Christopher A. ^{[1
]}

Rheingold, Arnold L. ^{[3
]}

DiPasquale, Antonio G. ^{[3
]}

Jensen, Paul R. ^{[1
]}

Fenical, William ^{[1
]}

机构：

[1] Univ Calif San Diego, Scripps Inst Oceanog, Ctr Marine Biotechnol & Biomed, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Grad Program Neurosci, San Diego, CA 92093 USA

[3] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2014年 / 77卷 / 01期

关键词：

PHYSICOCHEMICAL PROPERTIES; ANTIBIOTICS-SF2415; ANTIBACTERIAL; FERMENTATION; TAXONOMY;

D O I：

10.1021/np400466j

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The microbial production, isolation, and structure elucidation of four new napyradiomycin congeners (1-4) is reported. The structures of these compounds, which are new additions to the marine-derived meroterpenoids, were defined by comprehensive spectroscopic analysis and by X-ray crystallography. Using fluorescence-activated cell sorting (FACS) analysis, napyradiomycins 1-4 were observed to induce apoptosis in the colon adenocarcinoma cell line HCT-116, indicating the possibility of a specific biochemical target for this 1 class of cytotoxins.

引用

页码：15 / 21

页数：7

共 14 条

[1] Cytotoxic and Antimicrobial Napyradiomycins from Two Marine-Derived Streptomyces Strains [J].

Cheng, Yuan-Bin ;

Jensen, Paul R. ;

Fenical, William .

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2013, 2013 (18) :3751-3757

[2] STUDIES ON THE MECHANISM OF ACTION OF A80915A, A SEMI-NAPHTHOQUINONE NATURAL PRODUCT, AS AN INHIBITOR OF GASTRIC (H+-K+)-ATPASE [J].

DANTZIG, AH ;

MINOR, PL ;

GARRIGUS, JL ;

FUKUDA, DS ;

MYNDERSE, JS .

BIOCHEMICAL PHARMACOLOGY, 1991, 42 (10) :2019-2026

[3] A80915, A NEW ANTIBIOTIC COMPLEX PRODUCED BY STREPTOMYCES-ACULEOLATUS - DISCOVERY, TAXONOMY, FERMENTATION, ISOLATION, CHARACTERIZATION, AND ANTIBACTERIAL EVALUATION [J].

FUKUDA, DS ;

MYNDERSE, JS ;

BAKER, PJ ;

BERRY, DM ;

BOECK, LD ;

YAO, RC ;

MERTZ, FP ;

NAKATSUKASA, WM ;

MABE, J ;

OTT, J ;

COUNTER, FT ;

ENSMINGER, PW ;

ALLEN, NE ;

ALBORN, WE ;

HOBBS, JN .

JOURNAL OF ANTIBIOTICS, 1990, 43 (06) :623-633

[4] Hybrid isoprenoid secondary metabolite production in terrestrial and marine actinomycetes [J].

Gallagher, Kelley A. ;

Fenical, William ;

Jensen, Paul R. .

CURRENT OPINION IN BIOTECHNOLOGY, 2010, 21 (06) :794-800

[5] STUDIES ON NEW ANTIBIOTICS-SF2415 .2. THE STRUCTURAL ELUCIDATION [J].

GOMI, S ;

OHUCHI, S ;

SASAKI, T ;

ITOH, J ;

SEZAKI, M .

JOURNAL OF ANTIBIOTICS, 1987, 40 (06) :740-749

[6] NAPYRADIOMYCIN-A AND NAPYRADIOMYCIN-B1 - NONSTEROIDAL ESTROGEN-RECEPTOR ANTAGONISTS PRODUCED BY A STREPTOMYCES [J].

HORI, Y ;

ABE, Y ;

SHIGEMATSU, N ;

GOTO, T ;

OKUHARA, M ;

KOHSAKA, M .

JOURNAL OF ANTIBIOTICS, 1993, 46 (12) :1890-1893

[7] Lucifer's labyrinth - Ten years of path finding in cell death [J].

Meier, Pascal ;

Vousden, Karen H. .

MOLECULAR CELL, 2007, 28 (05) :746-754

[8] Natural products as sources of new drugs over the last 25 years [J].

Newman, David J. ;

Cragg, Gordon M. .

JOURNAL OF NATURAL PRODUCTS, 2007, 70 (03) :461-477

[9] NEW ANTIBIOTIC NAPYRADIOMYCINS A2 AND B4 AND STEREOCHEMISTRY OF NAPYRADIOMYCINS [J].

SHIOMI, K ;

NAKAMURA, H ;

IINUMA, H ;

NAGANAWA, H ;

TAKEUCHI, T ;

UMEZAWA, H ;

IITAKA, Y .

JOURNAL OF ANTIBIOTICS, 1987, 40 (09) :1213-1219

[10] NOVEL ANTIBIOTICS NAPYRADIOMYCINS - PRODUCTION, ISOLATION, PHYSICOCHEMICAL PROPERTIES AND BIOLOGICAL-ACTIVITY [J].

SHIOMI, K ;

IINUMA, H ;

HAMADA, M ;

NAGANAWA, H ;

MANABE, M ;

MATSUKI, C ;

TAKEUCHI, T ;

UMEZAWA, H .

JOURNAL OF ANTIBIOTICS, 1986, 39 (04) :487-493

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