Insertional oncogenesis in gene therapy: how much of a risk?

被引：70
作者：
Sadelain, M [1 ]
机构：
[1] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA
来源：
GENE THERAPY | 2004年 / 11卷 / 07期
关键词：
D O I：
10.1038/sj.gt.3302243
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
[No abstract available]
引用
收藏
页码：569 / 573
页数：5
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共 26 条
  • [1] Safety of retroviral gene marking with a truncated NGF receptor
    Bonini, C
    Grez, M
    Traversari, C
    Ciceri, F
    Marktel, S
    Ferrari, G
    Dinauer, M
    Sadat, M
    Aiuti, A
    Deola, S
    Radrizzani, M
    Hagenbeek, A
    Apperley, J
    Ebeling, S
    Martens, A
    Kolb, HJ
    Weber, M
    Lotti, F
    Grande, A
    Weissinger, E
    Bueren, JA
    Lamana, M
    Falkenburg, JHF
    Heemskerk, MHM
    Austin, T
    Kornblau, S
    Marini, F
    Benati, C
    Magnani, Z
    Cazzaniga, S
    Toma, S
    Gallo-Stampino, C
    Introna, M
    Slavin, S
    Greenberg, PD
    Bregni, M
    Mavilio, F
    Bordignon, C
    [J]. NATURE MEDICINE, 2003, 9 (04) : 367 - 369
  • [2] Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease
    Cavazzana-Calvo, M
    Hacein-Bey, S
    Basile, CD
    Gross, F
    Yvon, E
    Nusbaum, P
    Selz, F
    Hue, C
    Certain, S
    Casanova, JL
    Bousso, P
    Le Deist, F
    Fischer, A
    [J]. SCIENCE, 2000, 288 (5466) : 669 - 672
  • [3] Gene therapy insertional mutagenesis insights
    Davé, UP
    Jenkins, NA
    Copeland, NG
    [J]. SCIENCE, 2004, 303 (5656) : 333 - 333
  • [4] Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia
    Ferrando, AA
    Neuberg, DS
    Staunton, J
    Loh, ML
    Huard, C
    Raimondi, SC
    Behm, FG
    Pui, CH
    Downing, JR
    Gilliland, DG
    Lander, ES
    Golub, TR
    Look, AT
    [J]. CANCER CELL, 2002, 1 (01) : 75 - 87
  • [5] FUTURE FOR GENE THERAPY - RE-EVALUATION
    FRIEDMANN, T
    [J]. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1976, 265 (JAN23) : 141 - 152
  • [6] Gene therapy's new era: A balance of unequivocal benefit and unequivocal harm
    Friedmann, T
    [J]. MOLECULAR THERAPY, 2003, 8 (01) : 5 - 7
  • [7] Chromatin insulators and boundaries: Effects on transcription and nuclear organization
    Gerasimova, TI
    Corces, VG
    [J]. ANNUAL REVIEW OF GENETICS, 2001, 35 : 193 - 208
  • [8] Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapy
    Hacein-Bey-Abina, S
    Le Deist, F
    Carlier, F
    Bouneaud, C
    Hue, C
    De Villartay, JP
    Thrasher, AJ
    Wulffraat, N
    Sorensen, R
    Dupuis-Girod, S
    Fischer, A
    Cavazzana-Calvo, M
    Davies, EG
    Kuis, W
    Lundlaan, WHK
    Leiva, L
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2002, 346 (16) : 1185 - 1193
  • [9] LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1
    Hacein-Bey-Abina, S
    Von Kalle, C
    Schmidt, M
    McCcormack, MP
    Wulffraat, N
    Leboulch, P
    Lim, A
    Osborne, CS
    Pawliuk, R
    Morillon, E
    Sorensen, R
    Forster, A
    Fraser, P
    Cohen, JI
    de Saint Basile, G
    Alexander, I
    Wintergerst, U
    Frebourg, T
    Aurias, A
    Stoppa-Lyonnet, D
    Romana, S
    Radford-Weiss, I
    Gross, F
    Valensi, F
    Delabesse, E
    Macintyre, E
    Sigaux, F
    Soulier, J
    Leiva, LE
    Wissler, M
    Prinz, C
    Rabbitts, TH
    Le Deist, F
    Fischer, A
    Cavazzana-Calvo, M
    [J]. SCIENCE, 2003, 302 (5644) : 415 - 419
  • [10] A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency
    Hacein-Bey-Abina, S
    von Kalle, C
    Schmidt, M
    Le Deist, F
    Wulffraat, N
    McIntyre, E
    Radford, I
    Villeval, JL
    Fraser, CC
    Cavazzana-Calvo, M
    Fischer, A
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (03) : 255 - 256
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