MOLECULAR LINKS BETWEEN ALZHEIMER'S DISEASE AND DIABETES MELLITUS

被引：163

作者：

Yang, Y. ^{[1
]}

Song, W. ^{[1
]}

机构：

[1] Univ British Columbia, Grad Program Neurosci, Brain Res Ctr, Townsend Family Labs,Dept Psychiat, Vancouver, BC V6T 1Z3, Canada

来源：

NEUROSCIENCE | 2013年 / 250卷

基金：

加拿大健康研究院;

关键词：

Alzheimer's disease; diabetes; molecular links; ISLET AMYLOID POLYPEPTIDE; INSULIN-DEGRADING ENZYME; GLYCATION END-PRODUCTS; CYTOCHROME-C-OXIDASE; TRANSGENIC MOUSE MODEL; HIPPOCAMPAL SYNAPTIC PLASTICITY; RANDOMIZED CONTROLLED-TRIAL; GROWTH-FACTOR EXPRESSION; FREE-RADICAL GENERATION; A-BETA ACCUMULATION;

D O I：

10.1016/j.neuroscience.2013.07.009

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Substantial epidemiological evidence shows an increased risk for developing Alzheimer's disease (AD) in people with diabetes. Yet the underlying molecular mechanisms still remain to be elucidated. This article reviews the current studies on common pathological processes of Alzheimer's disease and diabetes with particular focus on potential mechanisms through which diabetes affects the initiation and progression of Alzheimer's disease. Impairment of insulin signaling, inflammation, oxidative stress, mitochondrial dysfunction, advanced glycation end products, APOE epsilon 4 and cholesterol appear to be important mediators and are likely to act synergistically in promoting AD pathology. (c) 2013 IBRO. Published by Elsevier Ltd. All rights reserved.

引用

页码：140 / 150

页数：11

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