Lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) serves as an endothelial receptor for advanced glycation end products (AGE)

被引：107
|
作者：
Jono, T
Miyazaki, A
Nagai, R
Sawamura, T
Kitamura, T
Horiuchi, S
机构：
[1] Kumamoto Univ, Sch Med, Dept Biochem, Kumamoto 8600811, Japan
[2] Kumamoto Univ, Sch Med, Dept Neuropsychiat, Kumamoto 8608556, Japan
[3] Natl Cardiovasc Ctr, Res Inst, Osaka 5658565, Japan
来源：
FEBS LETTERS | 2002年 / 511卷 / 1-3期
关键词：
advanced glycation end product; receptor for advanced glycation end products lectin-like oxidized low density lipoprotein receptor-1; endothelial cell;
D O I：
10.1016/S0014-5793(01)03325-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Advanced glycation end products (AGE) are known to serve as ligands for the scavenger receptors such as SR-A, CD36 and SR-BI. In the current study, we examined whether AGE is recognized by lectin-like oxidized low density lipoprotein receptor-1 (LOX-1). Cellular binding experiments revealed that AGE-bovine serum albumin (AGE-BSA) showed the specific binding to CHO cells overexpressing bovine LOV-1 (BLOX-1), which was effectively suppressed by an anti-BLOX-1 antibody. Cultured bovine aortic endothelial cells also showed the specific binding for AGE-BSA, which was suppressed by 67% by the antiBLOX-1 antibody. Thus, LOX-1 is identified as a novel endothelial receptor for AGE. (C) 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
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页码：170 / 174
页数：5
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