B7-H3 contributes to the development of pathogenic Th2 cells in a murine model of asthma

被引:26
作者
Nagashima, Osamu [1 ,2 ,3 ]
Harada, Norihiro [1 ,2 ,3 ]
Usui, Yoshihiko [1 ,4 ]
Yamazaki, Tomohide [1 ]
Yagita, Hideo [1 ]
Okumura, Ko [1 ]
Takahashi, Kazuhisa [2 ,3 ]
Akiba, Hisaya [1 ]
机构
[1] Juntendo Univ, Sch Med, Dept Immunol, Bunkyo Ku, Tokyo 1138421, Japan
[2] Juntendo Univ, Sch Med, Dept Resp Med, Tokyo 1138421, Japan
[3] Juntendo Univ, Sch Med, Res Inst Dis Old Ages, Tokyo 1138421, Japan
[4] Tokyo Med Univ, Dept Ophthalmol, Tokyo, Japan
关键词
D O I
10.4049/jimmunol.181.6.4062
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
B7-H3 is a new member of the B7 family. The receptor for B7-H3 has not been identified, but it seems to be expressed on activated T cells. Initial studies have shown that B7-H3 provides a stimulatory signal to T cells. However, recent studies suggest a negative regulatory role for B7-H3 in T cell responses. Thus, the immunological function of B7-H3 is controversial and unclear. In this study, we investigated the effects of neutralizing anti-B7-H3 mAb in a mouse model of allergic asthma to determine whether B7-H3 contributes to the development of pathogenic Th2 cells and pulmonary inflammation. Administration of anti-B7-H3 mAb significantly reduced airway hyperreactivity with a concomitant decrease in eosinophils in the lung as compared with control IgG-treated mice. Treatment with anti-B7-H3 mAb also resulted in decreased production of Th2 cytokines (IL-4, IL-5, and IL-13) in the draining lymph node cells. Although blockade of B7-H3 during the induction phase abrogated the development of asthmatic responses, B7-H3 blockade during the effector phase did not inhibit asthmatic responses. These results indicated an important role for B7-H3 in the development of pathogenic Th2 cells during the induction phase in a murine model of asthma.
引用
收藏
页码:4062 / 4071
页数:10
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