Aethiopinone, an antibacterial and cytotoxic agent from Salvia aethiopis roots

被引:20
作者
Hernández-Pérez, M
Rabanal, RM
Arias, A
de La Torre, MC
Rodríguez, B
机构
[1] Univ La Laguna, Dept Med Fis & Farmacol, Tenerife 38203, Spain
[2] Univ La Laguna, Dept Med Preventiva & Salud Publ, Tenerife 38203, Spain
[3] CSIC, Inst Quim Organ, Madrid, Spain
关键词
Salvia aethiopis; roots; aethiopinone; diterpenoid quinones; antimicrobial and cytotoxic activities;
D O I
10.1076/phbi.37.1.17.6321
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Roots of Salvia aethiopis L. were investigated for antimicrobial activity due to their reported medicinal use. Bioassay-guided fractionation of the crude extracts from the roots led to Me2CO extract as most active, exhibiting antibacterial activity against Staphylococcus aureus, Staphylococcus epidermidis, Micrococcus luteus, Bacillus subtilis and Bordetella bronchiseptica The highest antimicrobial activity with MICs values of 2.44 mu g/ml and 1.22 mu g/ml against S. epidermidis and B. subtilis, respectively, was observed with aethiopinone (1), which also showed cytotoxic activity towards cultured KB human carcinoma cells with an ED50 value of 0.62 mu g/ml.
引用
收藏
页码:17 / 21
页数:5
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