Association analysis of ZNF804A (zinc finger protein 804A) rs1344706 with therapeutic response to atypical antipsychotics in first-episode Chinese patients with schizophrenia

被引：16

作者：

Zhang, Jinbei ^{[1
]}

Wu, Xiaoli ^{[1
]}

Diao, Feici ^{[1
]}

Gan, Zhaoyu ^{[1
]}

Zhong, Zhiyong ^{[1
]}

Wei, Qingling ^{[1
]}

Guan, Nianhong ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Dept Psychiat, Affiliated Hosp 3, Guangzhou 510630, Guangdong, Peoples R China

来源：

COMPREHENSIVE PSYCHIATRY | 2012年 / 53卷 / 07期

关键词：

PROMOTER REGION VARIATION; COMMON VARIANTS; GENE ZNF804A; RISK GENE; POLYMORPHISM; LOCI;

D O I：

10.1016/j.comppsych.2012.02.002

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

The single-nucleotide polymorphism rs1344706 located in the ZNF804A zinc finger protein 804A gene is a well-established genome-wide significant variant for schizophrenia. The aim of this study was to investigate the potential association between this ZNF804A polymorphism and treatment response to atypical antipsychotic. Seventy-one first-episode inpatients with schizophrenia receiving olanzapine, aripiprazole, or quetiapine monotherapy were enrolled. Symptom response to treatment was assessed using the Positive and Negative Syndrome Scale (PANSS) on admission and reassessed after 4 weeks of treatment. Single-nucleotide polymorphism rs1344706 was genotyped by direct sequencing. There was substantial difference in treatment response among patients with 3 different genotypes regarding total PANSS score and positive subscore (for total PANSS score, F = 4.608, df = 2, P = .013; for positive subscore, F = 4.183, df = 2, P = .019). Compared with G homozygotes, T carriers showed significantly less improvement in total PANSS score as well as positive subscore (for total PANSS score, F = 8.724, df = 1, P = .004; for positive subscore, F = 9.392, df = 1, P = .005). Our results suggest that ZNF80A rs1344706 polymorphism may play a role in treatment response to atypical antipsychotic, although replication is required to confirm this finding. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：1044 / 1048

页数：5

共 19 条

[1] Neurotransmitter-related genes and antipsychotic response: pharmacogenetics meets psychiatric treatment [J].

Arranz, MJ ;

Kerwin, RW .

ANNALS OF MEDICINE, 2000, 32 (02) :128-133

[2] Clinical symptomatology and the psychosis risk gene ZNF804A [J].

Cummings, E. ;

Donohoe, G. ;

McDonald, C. ;

Dinan, T. G. ;

O'Neill, F. A. ;

O'Callaghan, E. ;

Waddington, J. L. ;

Murphy, K. C. ;

Gill, M. ;

Morris, D. W. ;

Corvin, A. .

SCHIZOPHRENIA RESEARCH, 2010, 122 (1-3) :273-275

[3] ZNF804A risk allele is associated with relatively intact gray matter volume in patients with schizophrenia [J].

Donohoe, Gary ;

Rose, Emma ;

Frodl, Thomas ;

Morris, Derek ;

Spoletini, Ilaria ;

Adriano, Fulvia ;

Bernardini, Sergio ;

Caltagirone, Carlo ;

Bossu, Paola ;

Gill, Michael ;

Corvin, Aiden P. ;

Spalletta, Gianfranco .

NEUROIMAGE, 2011, 54 (03) :2132-2137

[4] Neural Mechanisms of a Genome-Wide Supported Psychosis Variant [J].

Esslinger, Christine ;

Walter, Henrik ;

Kirsch, Peter ;

Erk, Susanne ;

Schnell, Knut ;

Arnold, Claudia ;

Haddad, Leila ;

Mier, Daniela ;

von Boberfeld, Carola Opitz ;

Raab, Kyeon ;

Witt, Stephanie H. ;

Rietschel, Marcella ;

Cichon, Sven ;

Meyer-Lindenberg, Andreas .

SCIENCE, 2009, 324 (5927) :605-605

[5] DRD2 promoter region variation as a predictor of sustained response to antipsychotic medication in first-episode schizophrenia patients [J].

Lencz, T ;

Robinson, DG ;

Xu, K ;

Ekholm, J ;

Sevy, S ;

Gunduz-Bruce, H ;

Woerner, MG ;

Kane, JM ;

Goldman, D ;

Malhotra, AK .

AMERICAN JOURNAL OF PSYCHIATRY, 2006, 163 (03) :529-531

[6] A Schizophrenia Risk Gene, ZNF804A, Influences Neuroanatomical and Neurocognitive Phenotypes [J].

Lencz, Todd ;

Szeszko, Philip R. ;

DeRosse, Pamela ;

Burdick, Katherine E. ;

Bromet, Evelyn J. ;

Bilder, Robert M. ;

Malhotra, Anil K. .

NEUROPSYCHOPHARMACOLOGY, 2010, 35 (11) :2284-2291

[7] DRD2 promoter region variation predicts antipsychotic-induced weight gain in first episode schizophrenia [J].

Lencz, Todd ;

Robinson, Delbert G. ;

Napolitano, Barbara ;

Sevy, Serge ;

Kane, John M. ;

Goldman, David ;

Malhotra, Anil K. .

PHARMACOGENETICS AND GENOMICS, 2010, 20 (09) :569-572

[8] Identification of loci associated with schizophrenia by genome-wide association and follow-up [J].

O'Donovan, Michael C. ;

Craddock, Nicholas ;

Norton, Nadine ;

Williams, Hywel ;

Peirce, Timothy ;

Moskvina, Valentina ;

Nikolov, Ivan ;

Hamshere, Marian ;

Carroll, Liam ;

Georgieva, Lyudmila ;

Dwyer, Sarah ;

Holmans, Peter ;

Marchini, Jonathan L. ;

Spencer, Chris C. A. ;

Howie, Bryan ;

Leung, Hin-Tak ;

Hartmann, Annette M. ;

Moeller, Hans-Juergen ;

Morris, Derek W. ;

Shi, YongYong ;

Feng, GuoYin ;

Hoffmann, Per ;

Propping, Peter ;

Vasilescu, Catalina ;

Maier, Wolfgang ;

Rietschel, Marcella ;

Zammit, Stanley ;

Schumacher, Johannes ;

Quinn, Emma M. ;

Schulze, Thomas G. ;

Williams, Nigel M. ;

Giegling, Ina ;

Iwata, Nakao ;

Ikeda, Masashi ;

Darvasi, Ariel ;

Shifman, Sagiv ;

He, Lin ;

Duan, Jubao ;

Sanders, Alan R. ;

Levinson, Douglas F. ;

Gejman, Pablo V. ;

Cichon, Sven ;

Noethen, Markus M. ;

Gill, Michael ;

Corvin, Aiden ;

Rujescu, Dan ;

Kirov, George ;

Owen, Michael J. .

NATURE GENETICS, 2008, 40 (09) :1053-1055

[9] Common polygenic variation contributes to risk of schizophrenia and bipolar disorder [J].

Purcell, Shaun M. ;

Wray, Naomi R. ;

Stone, Jennifer L. ;

Visscher, Peter M. ;

O'Donovan, Michael C. ;

Sullivan, Patrick F. ;

Sklar, Pamela ;

Ruderfer, Douglas M. ;

McQuillin, Andrew ;

Morris, Derek W. ;

O'Dushlaine, Colm T. ;

Corvin, Aiden ;

Holmans, Peter A. ;

Macgregor, Stuart ;

Gurling, Hugh ;

Blackwood, Douglas H. R. ;

Craddock, Nick J. ;

Gill, Michael ;

Hultman, Christina M. ;

Kirov, George K. ;

Lichtenstein, Paul ;

Muir, Walter J. ;

Owen, Michael J. ;

Pato, Carlos N. ;

Scolnick, Edward M. ;

St Clair, David ;

Williams, Nigel M. ;

Georgieva, Lyudmila ;

Nikolov, Ivan ;

Norton, N. ;

Williams, H. ;

Toncheva, Draga ;

Milanova, Vihra ;

Thelander, Emma F. ;

Sullivan, Patrick ;

Kenny, Elaine ;

Quinn, Emma M. ;

Choudhury, Khalid ;

Datta, Susmita ;

Pimm, Jonathan ;

Thirumalai, Srinivasa ;

Puri, Vinay ;

Krasucki, Robert ;

Lawrence, Jacob ;

Quested, Digby ;

Bass, Nicholas ;

Crombie, Caroline ;

Fraser, Gillian ;

Kuan, Soh Leh ;

Walker, Nicholas .

NATURE, 2009, 460 (7256) :748-752

[10] Replication of association between schizophrenia and ZNF804A in the Irish Case-Control Study of Schizophrenia sample [J].

Riley, B. ;

Thiselton, D. ;

Maher, B. S. ;

Bigdeli, T. ;

Wormley, B. ;

McMichael, G. O. ;

Fanous, A. H. ;

Vladimirov, V. ;

O'Neill, F. A. ;

Walsh, D. ;

Kendler, K. S. .

MOLECULAR PSYCHIATRY, 2010, 15 (01) :29-37

← 1 2 →