Adalimumab treatment may replace or enhance the activity of steroids in steroid-refractory tuberculous meningitis

被引：21
作者：
Lee, Ho-Su [1 ]
Lee, Yumi [1 ]
Lee, Sang-Oh [1 ]
Choi, Sang-Ho [1 ]
Kim, Yang Soo [1 ]
Woo, Jun Hee [1 ]
Kim, Sung-Han [1 ]
机构：
[1] Univ Ulsan, Dept Infect Dis, Asan Med Ctr, Coll Med, Seoul 138736, South Korea
来源：
JOURNAL OF INFECTION AND CHEMOTHERAPY | 2012年 / 18卷 / 04期
关键词：
Tuberculosis; Paradoxical reaction; Steroid-refractory; Tumor necrosis factor inhibitor; Adalimumab; THALIDOMIDE; THERAPY;
D O I：
10.1007/s10156-011-0334-y
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
We describe a paradoxical response involving the central nervous system in a patient with steroid-refractory tuberculous meningitis that was unresponsive to systemic corticosteroids but was improved with adalimumab. The immunomodulatory effect of tumor necrosis factor inhibitors may have a role in replacing or enhancing the activity of steroids in the management of steroid-refractory tuberculous meningitis.
引用
收藏
页码：555 / 557
页数：3
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