Genome-wide screening for genetic changes in a matched pair of benign and prostate cancer cell lines using array CGH

被引：16

作者：

Brookman-Amissah, N

Duchesnes, C

Williamson, MP

Wang, Q

Ahmed, A

Feneley, MR

Mackay, A

Freeman, A

Fenwick, K

Iravani, M

Weber, B

Ashworth, A

Masters, JR

机构：

[1] UCL, Prostate Canc Res Ctr, Inst Urol, London W1W 7EJ, England

[2] Inst Canc Res, Breakthrough Toby Robins Breast Canc Res Ctr, London SW3 6JB, England

[3] Univ Penn, Abramson Family Canc Res Inst, Philadelphia, PA 19104 USA

来源：

PROSTATE CANCER AND PROSTATIC DISEASES | 2005年 / 8卷 / 04期

基金：

英国医学研究理事会;

关键词：

aCGH; prostate cancer cell lines; genetic changes;

D O I：

10.1038/sj.pcan.4500826

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Copy number alterations in a matched pair of benign epithelial and prostate cancer cell lines derived from the same patient were assessed using array-based comparative genomic hybridisation (aCGH). The cancer cell line showed a gain of chromosome 7, deletion of chromosome 8, gains ( including high level) and losses on chromosome 11, loss of 18p and gain of 20q. Deletions on chromosome 8 were confirmed with microsatellite markers. The aCGH results were compared to gene expression data obtained using DNA microarrays and suggested the involvement of caspases and ICEBERG on 11q and E2F1 on chromosome 20q.

引用

页码：335 / 343

页数：9

共 27 条

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