The effect of a spot-on formulation containing polyunsaturated fatty acids and essential oils on dogs with atopic dermatitis

被引:43
作者
Blaskovic, M. [1 ]
Rosenkrantz, W. [2 ]
Neuber, A. [3 ]
Sauter-Louis, C. [4 ]
Mueller, R. S. [1 ]
机构
[1] Univ Munich, Clin Small Anim Med, Ctr Clin Vet Med, D-80539 Munich, Germany
[2] Anim Dermatol Clin, Tustin, CA 92780 USA
[3] Chiltern Referral Serv, Clin Derm4Pets, Chalfont St Giles HP8 4AB, Bucks, England
[4] Univ Munich, Clin Ruminants, Ctr Clin Vet Med, D-85764 Oberschleissheim, Germany
关键词
Atopic dermatitis; Canine; Essential fatty acids; Topical therapy; ACVD TASK-FORCE; ALLERGIC PRURITUS; STRATUM-CORNEUM; CANINE; SKIN; SEVERITY; EXPRESSION; MANAGEMENT; DIET; SUPPLEMENTATION;
D O I
10.1016/j.tvjl.2013.10.024
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
Recent studies have shown that immunological aberrations and epidermal barrier defects could be important in the pathogenesis of canine atopic dermatitis (CAD) and that oral polyunsaturated fatty acids (PUFAs) might influence the epidermal barrier. The aim of this study was to evaluate the effects of a spot-on formulation containing PUFAs and essential oils on pruritus and lesions caused by CAD. Forty-eight privately owned dogs of different breeds, ages and genders diagnosed with atopic dermatitis were included in a randomized, double-blinded, placebo-controlled, multicentre clinical trial. Dogs were treated with a spot-on formulation containing PUFAs and essential oils or placebo on the dorsal neck once weekly for 8 weeks. Before and after the study, CAD extent and severity index-03 (CADESI-03) and pruritus scores were determined by veterinarians and owners, respectively. There was significantly more improvement in CADESI-03 and pruritus scores in the treatment group than in the placebo group (P = 0.011 and P = 0.036, respectively). Additionally, more dogs improved by at least 50% in CADESI-03 and pruritus scores in the treatment group than in the placebo group (P = 0.008 and P = 0.070, respectively). No adverse reactions were observed. The topical preparation containing PUFAs and essential oils was a safe treatment and beneficial in ameliorating the clinical signs of CAD. (C) 2013 The Authors. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:39 / 43
页数:5
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