Anti-influenza virus drug design: Sialidase inhibitors

被引：17
|
作者：
Dyason, JC [1 ]
von Itzstein, M [1 ]
机构：
[1] Griffith Univ, Ctr Biomol Sci & Drug Discovery, Southport, Qld 9726, Australia
来源：
AUSTRALIAN JOURNAL OF CHEMISTRY | 2001年 / 54卷 / 11期
关键词：
D O I：
10.1071/CH01173
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
This review will give an overview of the design process behind the development of sialidase inhibitors, which can be used as anti-influenza drugs. Two drugs (Relenza(TM) and Tamiflu(TM)) are already available as prescription drugs and a third (BCX-1812) is currently undergoing third-phase clinical trials. Also, the use of molecular-modelling techniques in the understanding of the mechanism and the prediction of inhibition of this enzyme is reviewed.
引用
收藏
页码：663 / 670
页数：8
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