Glucocorticoids and osteocyte autophagy

被引：73

作者：

Yao, Wei ^{[1
]}

Dai, Weiwei ^{[1
]}

Jiang, Jean X. ^{[2
]}

Lane, Nancy E. ^{[1
]}

机构：

[1] Univ Calif Davis, Med Ctr, Dept Med, Sacramento, CA 95818 USA

[2] Univ Texas Hlth Sci Ctr San Antonio, Dept Biochem, San Antonio, TX 78229 USA

来源：

BONE | 2013年 / 54卷 / 02期

关键词：

Glucocorticoids; Autophagy; Bone fragility; CORTICOSTEROID-INDUCED OSTEOPOROSIS; RANDOMIZED CONTROLLED-TRIAL; DOUBLE-EDGED-SWORD; BONE-DENSITY; OSTEOBLAST DIFFERENTIATION; MATRIX MINERALIZATION; MULTIFUNCTIONAL CELLS; OXIDATIVE STRESS; TREATED MICE; FGF23;

D O I：

10.1016/j.bone.2013.01.034

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Glucocorticoids are used for the treatment of inflammatory and autoimmune diseases. While they are effective therapy, bone loss and incident fracture risk are high. While previous studies have found GC effects on both osteoclasts and osteoblasts, our work has focused on the effects of GCs on osteocytes. Osteocytes exposed to low dose GCs undergo autophagy while osteocytes exposed to high doses of GCs or for a prolonged period of time undergo apoptosis. This paper will review the data to support the role of GCs in osteocyte autophagy. This article is part of a Special Issue entitled "The Osteocyte". (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：279 / 284

页数：6

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