An update on lipotoxic endoplasmic reticulum stress in pancreatic β-cells

被引：58

作者：

Cnop, Miriam ^{[1
,2
]}

Igoillo-Esteve, Mariana ^{[1
]}

Cunha, Daniel A. ^{[1
]}

Ladriere, Laurence ^{[1
]}

Eizirik, Decio L. ^{[1
]}

机构：

[1] Univ Libre Bruxelles, Expt Med Lab, B-1070 Brussels, Belgium

[2] Erasmus Hosp, Div Endocrinol, B-1070 Brussels, Belgium

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2008年 / 36卷

关键词：

apoptosis; diabetes; endoplasmic reticulum stress (ER Stress); insulin; lipotoxicity; pancreatic beta-cell;

D O I：

10.1042/BST0360909

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The OR (unfolded protein response) or ER (endoplasmic reticulum) stress response was first described 20 years ago. The field of ER stress has expanded tremendously since, moving from basic biology in yeast to human neurodegenerative, inflammatory, cardiovascular and neoplastic diseases. The ER stress response has also been implicated in diabetes development, affecting both insulin production by pancreatic beta-cells and insulin sensitivity in peripheral tissues. In the present mini-review, we focus on recent progress in the field of ER stress in pancreatic beta-cells. Recent advances in the understanding of lipotoxic ER stress and p-cell recovery from ER stress are discussed.

引用

页码：909 / 915

页数：7

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