Risk of infantile hemangiomas in the offspring of women with autoimmune disease and the pathogenic implications of these lesions

被引:7
作者
Smith, Chelsey J. F. [1 ]
Jones, Kenneth L. [2 ]
Johnson, Diana L. [2 ]
Bandoli, Gretchen [2 ]
Robinson, Loan K. [2 ]
Kavanaugh, Arthur [1 ]
Chambers, Christina D. [2 ]
机构
[1] Univ Calif San Diego, Div Rheumatol, Immunol, Allergy, La Jolla, CA 92093 USA
[2] Univ Calif San Diego, Dept Pediat, San Diego, CA 92103 USA
基金
美国国家卫生研究院;
关键词
autoimmune; biologics; birth defects; infantile hemangioma; pregnancy; INFLAMMATORY-BOWEL-DISEASE; ADVERSE PREGNANCY OUTCOMES; RHEUMATOID-ARTHRITIS; HYPOXIA; QUESTIONNAIRE; ANGIOGENESIS; ANOMALIES; BIRTH; HIF;
D O I
10.1002/ajmg.a.38594
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The purpose of this study was to analyze the risk of maternal autoimmune disease or associated treatments on infantile hemangiomas (IHs), a common benign vascular tumor in infants, and to better understand how maternal chronic inflammation may play a factor in the pathogenesis of these lesions. Eligible women from the United States and Canada who enrolled before 19 weeks' gestation and delivered at least one live born infant were recruited as part of the Organization of Teratology Information Specialists (OTIS) Autoimmune Disease in Pregnancy Project from 2004-2013. A total of 51/969 (5.3%) and 8/240 (3.3%) infants with IH were born to mothers with and without autoimmune disease, respectively (OR 1.61; 95%CI, 0.75-.44). The presence of ulcerative colitis (UC) in the mother was significantly associated with IH in the child (OR 3.46; 95%CI, 1.29-9.26). The five largest IH occurred within the autoimmune disease cohort and to women taking a biologic medication. These results imply that UC may be a risk factor for IH development, and that chronic inflammation may influence the development of these lesions. This potential link between IH and autoimmune disease warrants further investigation.
引用
收藏
页码:570 / 577
页数:8
相关论文
共 30 条
[1]  
Alfirevic Z., 2003, COCHRANE DB SYST REV, V3
[2]   Maternal cytokines and disease severity influence pregnancy outcomes in women with rheumatoid arthritis [J].
Atta, Doaa S. ;
Girbash, Ehab F. ;
Abdelwahab, Shaimaa M. ;
Abdeldayem, Hussein M. ;
Tharwat, Ibrahim ;
Ghonaim, Rania .
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, 2016, 29 (20) :3358-3363
[3]   Hemangioma in the newborn: increased incidence after chorionic villus sampling [J].
Bauland, Constantijn G. ;
Smit, Jeroen M. ;
Bartelink, Lidewij R. ;
Zondervan, Hans A. ;
Spauwen, Paul H. M. .
PRENATAL DIAGNOSIS, 2010, 30 (10) :913-917
[4]   The role of hypoxia in inflammatory disease [J].
Biddlestone, John ;
Bandarra, Daniel ;
Rocha, Sonia .
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2015, 35 (04) :859-869
[5]  
Bruce B, 2003, J RHEUMATOL, V30, P167
[6]   AN INCREASED INCIDENCE OF HEMANGIOMAS IN INFANTS BORN FOLLOWING CHORIONIC VILLUS SAMPLING (CVS) [J].
BURTON, BK ;
SCHULZ, CJ ;
ANGLE, B ;
BURD, LI .
PRENATAL DIAGNOSIS, 1995, 15 (03) :209-214
[7]   Postmarketing surveillance for human teratogenicity: A model approach [J].
Chambers, CD ;
Braddock, SR ;
Briggs, GG ;
Einarson, A ;
Johnson, YR ;
Miller, RK ;
Polifka, JE ;
Robinson, LK ;
Stepanuk, K ;
Jones, KL .
TERATOLOGY, 2001, 64 (05) :252-261
[8]   The role of HIF in immunity and inflammation [J].
Cummins, Eoin P. ;
Keogh, Ciara E. ;
Crean, Daniel ;
Taylor, Cormac T. .
MOLECULAR ASPECTS OF MEDICINE, 2016, 47-48 :24-34
[9]   Does hypoxia play a role in infantile hemangioma? [J].
de Jong, Sophie ;
Itinteang, Tinte ;
Withers, Aaron H. J. ;
Davis, Paul F. ;
Tan, Swee T. .
ARCHIVES OF DERMATOLOGICAL RESEARCH, 2016, 308 (04) :219-227
[10]  
El-Raggal N. M., 2017, CLIN APPL THROMB-HEM, V1