Antidiabetic effects of corosolic acid in KK-Ay diabetic mice

被引：58

作者：

Miura, T

Ueda, N

Yamada, K

Fukushima, M

Ishida, T

Kaneko, T

Matsuyama, F

Seino, Y

机构：

[1] Suzuka Univ Med Sci, Dept Clin Nutr, Suzuka, Mie 5100293, Japan

[2] Use Techno Corp Co Ltd, Kyoto 6200055, Japan

[3] Fdn Biomed Res & Innovat, Dept Hlth, Informat Ctr, Chuo Ku, Kobe, Hyogo 6500047, Japan

[4] Suzuka Univ Med Sci, Hitech Res Ctr, Suzuka, Mie 5100293, Japan

[5] Hiroshima Int Univ, Dept Pharmaceut Sci, Hiroshima 7370112, Japan

[6] Kyoto Univ, Dept Metab & Clin Nutr, Fac Med, Sakyo Ku, Kyoto 6060055, Japan

来源：

BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2006年 / 29卷 / 03期

关键词：

corosolic acid; antidiabetic effect; KK-Ay mice; insulin resistance;

D O I：

10.1248/bpb.29.585

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The antidiabetic effects of corosolic acid (CA) were investigated in KK-Ay mice, an animal model of type 2 diabetes. CA (2 mg/kg body weight) reduced the blood glucose levels of KK-Ay mice 4 h after a single oral dose. CA (2 mg/kg) reduced the blood glucose levels in KK-Ay mice 2 weeks after a single oral dose and also significantly lowered plasma insulin levels were in KK-Ay mice under similar conditions. CA-treated KK-Ay mouse blood glucose significantly decreased in an insulin tolerance test. These results support the hypothesis that CA improves glucose metabolism by reducing insulin resistance. Therefore CA may be useful for the treatment of type 2 diabetes.

引用

页码：585 / 587

页数：3

共 10 条

[1] ROLE OF OVARIAN HORMONES IN THE LONG-TERM CONTROL OF GLUCOSE-HOMEOSTASIS - EFFECTS ON INSULIN-SECRETION [J].