Antibody-drug conjugates ace the tolerability test

被引:15
作者
Damle, Nitin K. [1 ]
机构
[1] Wyeth Ayerst Res, Oncol Discovery Res Div, Pearl River, NY 10965 USA
关键词
D O I
10.1038/nbt0808-884
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Near-uniform, low-level conjugation of cytotoxins to antitumor antibodies increases their tolerability without compromising efficacy.
引用
收藏
页码:884 / 885
页数:3
相关论文
共 9 条
[1]   Antibody-drug conjugates for cancer therapy [J].
Carter, Paul J. ;
Senter, Peter D. .
CANCER JOURNAL, 2008, 14 (03) :154-169
[2]   Tumour-targeted chemotherapy with immunoconjugates of calicheamicin [J].
Damle, NK .
EXPERT OPINION ON BIOLOGICAL THERAPY, 2004, 4 (09) :1445-1452
[3]   Effects of drug loading on the antitumor activity of a monoclonal antibody drug conjugate [J].
Hamblett, KJ ;
Senter, PD ;
Chace, DF ;
Sun, MMC ;
Lenox, J ;
Cerveny, CG ;
Kissler, KM ;
Bernhardt, SX ;
Kopcha, AK ;
Zabinski, RF ;
Meyer, DL ;
Francisco, JA .
CLINICAL CANCER RESEARCH, 2004, 10 (20) :7063-7070
[4]   Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index [J].
Junutula, Jagath R. ;
Raab, Helga ;
Clark, Suzanna ;
Bhakta, Sunil ;
Leipold, Douglas D. ;
Weir, Sylvia ;
Chen, Yvonne ;
Simpson, Michelle ;
Tsai, Siao Ping ;
Dennis, Mark S. ;
Lu, Yanmei ;
Meng, Y. Gloria ;
Ng, Carl ;
Yang, Jihong ;
Lee, Chien C. ;
Duenas, Eileen ;
Gorrell, Jeffrey ;
Katta, Viswanatham ;
Kim, Amy ;
McDorman, Kevin ;
Flagella, Kelly ;
Venook, Rayna ;
Ross, Sarajane ;
Spencer, Susan D. ;
Wong, Wai Lee ;
Lowman, Henry B. ;
Vandlen, Richard ;
Sliwkowski, Mark X. ;
Scheller, Richard H. ;
Polakis, Paul ;
Mallet, William .
NATURE BIOTECHNOLOGY, 2008, 26 (08) :925-932
[5]   Drug-conjugated monoclonal antibodies for the treatment of cancer [J].
Lambert, JM .
CURRENT OPINION IN PHARMACOLOGY, 2005, 5 (05) :543-549
[6]   Engineered antibody-drug conjugates with defined sites and stoichiometries of drug attachment [J].
McDonagh, Charlotte F. ;
Turcott, Eileen ;
Westendorf, Lori ;
Webster, Jennifer B. ;
Alley, Stephen C. ;
Kim, Kristine ;
Andreyka, Jamie ;
Stone, Ivan ;
Hamblett, Kevin J. ;
Francisco, Joseph A. ;
Carter, Paul .
PROTEIN ENGINEERING DESIGN & SELECTION, 2006, 19 (07) :299-307
[7]   Phase I biodistribution study of Ley targeting immunoconjugate in advanced epithelial cancers [J].
Scott, A. M. ;
Herbertson, R. A. ;
Lee, F. T. ;
Chappell, B. ;
Micallef, N. ;
Lee, S. T. ;
Saunder, T. ;
Hopkins, W. ;
Smyth, F. E. ;
Tebbutt, N. C. .
JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (15)
[8]   Reduction-alkylation strategies for the modification of specific monoclonal antibody disulfides [J].
Sun, MMC ;
Beam, KS ;
Cerveny, CG ;
Hamblett, KJ ;
Blackmore, RS ;
Torgov, MY ;
Handley, FGM ;
Ihle, NC ;
Senter, PD ;
Alley, SC .
BIOCONJUGATE CHEMISTRY, 2005, 16 (05) :1282-1290
[9]   Arming antibodies: prospects and challenges for immunoconjugates [J].
Wu, AM ;
Senter, PD .
NATURE BIOTECHNOLOGY, 2005, 23 (09) :1137-1146