Triptorelin acetate-loaded poly(lactide-co-glycolide) (PLGA) microspheres for controlled drug delivery

被引：14
|
作者：
Park, Kyonghee [1 ,2 ]
Jung, Goo Young [3 ]
Kim, Myong-Ki [2 ]
Park, Mork Soon [3 ]
Shin, Yong Kook [2 ]
Hwang, Jae-Kwan [1 ,4 ]
Yuk, Soon Hong [5 ]
机构：
[1] Yonsei Univ, Dept Biomat Sci & Engn, Seoul 120749, South Korea
[2] Chungbuk Technopk, Chungbuk 363883, South Korea
[3] Dongkook Pharmaceut Co, Chungbuk 365830, South Korea
[4] Yonsei Univ, Coll Life Sci & Biotechnol, Dept Biotechnol, Seoul 120749, South Korea
[5] Korea Univ, Coll Pharm, Chungnam 339700, South Korea
来源：
MACROMOLECULAR RESEARCH | 2012年 / 20卷 / 08期
关键词：
triptorelin acetate; PLGA microspheres; controlled release; peptide drug; stability; mannitol; NANOPARTICLES; STABILITY; SOLVENT; CANCER; TRIAL;
D O I：
10.1007/s13233-012-0123-1
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Triptorelin acetate-loaded poly(lactide-co-glycolide) (PLGA) microspheres have been prepared in binary solvent mixtures composed of dichloromethane (DCM) and acetone (AC). The surface morphology of PLGA microspheres was examined by scanning electron microscopy with varying solvent composition, and the size distribution of PLGA microspheres was measured using a particle size analyzer. Triptorelin acetate is a luteinizing hormonereleasing hormone analog that is used as a model peptide drug. With the increase of AC content in the binary solvent mixture, PLGA microspheres with smooth surface were obtained and this led to an increased loading efficiency with the decreased particle size. For the application of PLGA microspheres as a controlled drug delivery system, the release pattern of triptorelin acetate was observed and the stability of triptorelin acetate-loaded PLGA microspheres was observed with or without mannitol. The sustained release pattern was observed after the initial burst effect and the improved stability of PLGA microspheres was observed with mannitol.
引用
收藏
页码：847 / 851
页数：5
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