Gonads directly regulate growth in teleosts

被引：51

作者：

Bhatta, Sandip ^{[1
]}

Iwai, Toshiharu ^{[1
]}

Miura, Chiemi ^{[1
]}

Higuchi, Masato ^{[1
]}

Shimizu-Yamaguchi, Sonoko ^{[1
]}

Fukada, Haruhisa ^{[2
]}

Miura, Takeshi ^{[1
]}

机构：

[1] Ehime Univ, S Ehime Fisheries Res Ctr, Res Grp Fish Reprod Physiol, Matsuyama, Ehime 7984292, Japan

[2] Kochi Univ, Fac Agr, Lab Fish Nutr, Kochi 7838502, Japan

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2012年 / 109卷 / 28期

基金：

日本学术振兴会;

关键词：

gonadal function; gonadal implantation; Mozambique tilapia; TROUT ONCORHYNCHUS-MYKISS; HORMONE GH; OREOCHROMIS-MOSSAMBICUS; FEMALE GOLDFISH; CHICKEN OVARY; FACTOR-I; EXPRESSION; PITUITARY; TILAPIA; TESTIS;

D O I：

10.1073/pnas.1118704109

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In general, there is a relationship between growth and reproduction, and gonads are known to be important organs for growth, but direct evidence for their role is lacking. Here, using a fish model, we report direct evidence that gonads are endocrine organs equal to the pituitary in controlling body growth. Gonadal loss of function, gain of function, and rescue of growth were investigated in tilapia. Gonadectomy experiments were carried out in juvenile males and females. Gonadectomy significantly retarded growth compared with controls; however, this retardation was rescued by the implantation of extirpated gonads. Because gonads express growth hormone, it is possible that gonads control body growth through the secretion of growth hormone and/or other endocrine factors. We propose that gonads are integral players in the dynamic regulation of growth in teleosts.

引用

页码：11408 / 11412

页数：5

共 34 条

[1] Previtellogenic oocyte growth in salmon: Relationships among body growth, plasma insulin-like growth factor-1, estradiol-17beta, follicle-stimulating hormone and expression of ovarian genes for insulin-like growth factors, steroidogenic-acute regulatory protein and receptors for gonadotropins, growth hormone, and somatolactin [J].