Near-Infrared Fluorescent Probes with Large Stokes Shifts for Sensing Zn(II) Ions in Living Cells

被引：61
|
作者：
Zhang, Shuwei [1 ]
Adhikari, Rashmi [1 ]
Fang, Mingxi [1 ]
Dorh, Nethaniah [1 ]
Li, Cong [1 ]
Jaishi, Meghnath [2 ]
Zhang, Jingtuo [1 ]
Tiwari, Ashutosh [1 ]
Pati, Ranjit [2 ]
Luo, Fen-Tair [3 ]
Liu, Haiying [1 ]
机构：
[1] Michigan Technol Univ, Dept Chem, Houghton, MI 49931 USA
[2] Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA
[3] Acad Sinica, Inst Chem, Taipei 11529, Taiwan
来源：
ACS SENSORS | 2016年 / 1卷 / 12期
基金：
美国国家科学基金会; 美国国家卫生研究院;
关键词：
fluorescent probe; near-infrared; Rhodol counterpart; Zn(II) ions; photoinduced electron transfer; ZINC IONS; MOBILE ZINC; ZN2+; SENSORS; RED; CHEMOSENSOR; DESIGN; DYES; PH;
D O I：
10.1021/acssensors.6b00490
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We report two new near-infrared fluorescent probes based on Rhodol counterpart fluorophore platforms functionalized with dipicolylamine Zn(II)-binding groups. The combinations of the pendant amines and fluorophores provide the probes with an effective three-nitrogen-atom and one-oxygen-atom binding motif. The fluorescent probes with large Stokes shifts offer sensitive and selective florescent responses to Zn(II) ions over other metal ions, allowing a reversible monitoring of Zn(II) concentration changes in living cells, and detecting intracellular Zn(II) ions released from intracellular metalloproteins.
引用
收藏
页码：1408 / 1415
页数：8
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