LEFT VENTRICULAR DIASTOLIC FUNCTIONAL STATUS AFTER CORONARY ARTERY BYPASS GRAFTING

Background: Improving or deteriorating effects of cardiac revascularization on left ventricular diastolic dysfunction especially concurrent with left ventricular systolic dysfunction is still controversial. Objectives: We aimed to compare diastolic functional status after coronary artery bypass grafting (CABG) with the baseline in patients with known coronary artery disease. Methods: Sixty consecutive patients with known coronary artery disease according to coronary angiography findings who were candidates for elective CABG were enrolled in a before-after interventional study. Before and also three months after CABG, the parameters of left ventricular diastolic function were measured by Doppler and tissue Doppler echocardiography by the Paired t test with considering p-value of less than 0.05 as significant. Results: The mean +/- SD age of the participants was59.6 +/- 8.7 years (range: 46-78 years) and 75% were men. With regard to the changes in echocardiography parameters, significant improvement in mean DT index (from 224 +/- 54 msec to 192 +/- 42 msec, p < 0.001), IVRT (from 104 +/- 22 msec to 85 +/- 13 msec, p < 0.001), E/Ea Ratio (from 11.19 +/- 3.74 to 9.30 +/- 2.67, P< 0.001), and LV ejection fraction (from 47.59 +/- 6.94% to 49.36 +/- 7.77%, P=0.007) was observed. Among all subjects, 56.6% experienced improvement in cardiac diastolic function index with more improvement in men than in women, non-diabetics compared with diabetics, normotensive compared with hypertensive individuals (57.1% versus 36.6%), and nonsmokers than in smokers. Younger patients also experienced more improvement in diastolic function index than the patients older than 60 years, however the improvement of these functional parameters remained independent to the number of involved coronary vessels. Conclusions: Improvement of left ventricular diastolic function can be achieved about three months after CABG surgery, independent to the severity of coronary artery diseas