Relation of uric acid level to rapid kidney function decline and development of kidney disease: The Jackson Heart Study

被引：32

作者：

Mwasongwe, Stanford E. ^{[1
]}

Fulop, Tibor ^{[2
,3
]}

Katz, Ronit ^{[4
]}

Musani, Solomon K. ^{[5
]}

Sims, Mario ^{[5
]}

Correa, Adolfo ^{[5
]}

Flessner, Michael F. ^{[6
]}

Young, Bessie A. ^{[4
,7
]}

机构：

[1] Jackson State Univ, Jackson Heart Study, Jackson, MS USA

[2] Med Univ South Carolina, Dept Med, Div Nephrol, Charleston, SC USA

[3] Ralph H Johnson VA Med Ctr, Med Serv, Charleston, SC USA

[4] Univ Washington, Div Nephrol, Kidney Res Inst, Seattle, WA 98195 USA

[5] Univ Mississippi, Med Ctr, Jackson Heart Study, Jackson, MS 39216 USA

[6] NIDDK, Bethesda, MD 20892 USA

[7] Vet Affairs Puget Sound Hlth Care Ctr, Seattle, WA USA

来源：

JOURNAL OF CLINICAL HYPERTENSION | 2018年 / 20卷 / 04期

关键词：

African American; albuminuria; chronic kidney disease; CKD progression; estimated glomerular filtration rate; rapid kidney function decline; uric acid; AFRICAN-AMERICANS; LOWERING THERAPY; SERUM CREATININE; RISK-FACTOR; PROGRESSION; POPULATION; HYPERURICEMIA; ASSOCIATION; HEALTH;

D O I：

10.1111/jch.13239

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Whether elevated uric acid (UA) is an independent risk factor for chronic kidney disease (CKD) is not well established. The authors evaluated the relationship of UA with rapid kidney function decline (RKFD) and incident CKD among 3702 African Americans (AAs) in the Jackson Heart Study with serum UA levels measured at baseline exam (2000-2004). RKFD was defined as 30% eGFR loss and incident CKD as development of eGFR <60mL/min/1.73m(2) with a 25% decline in eGFR between baseline and exam 3 (2009-2013). RKFD and CKD were found in 11.4% and 7.5% of the participants, respectively. In a fully adjusted model, the odds of RKFD (OR, 1.8; 95% CI, 1.25-2.49) and incident CKD (OR, 2.00; 95% CI, 1.31-3.06) were significantly higher among participants in the top UA quartile vs bottom quartile. In the JHS, elevated UA was significantly associated with RKFD and incident CKD.

引用

页码：775 / 783

页数：9

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