Recent Developments in the Synthesis of Fluorine-Containing β-Amino Acids and β-Lactams

Fluorine-containing beta-amino acids and beta-lactams have attracted appreciable attention due to their wide application in organic chemistry, drug discovery, and protein biology. Accordingly, the development of efficient synthetic methods is of considerable interest in academia and industry. The synthesis and resolution are achieved. This review briefly summarizes the recent development in the methodologies for the synthesis of fluorine-containing beta-amino acids and beta-lactams with classification by the species of the fluorine-containing beta-amino acids (alpha-fluorinated beta-amino acids, alpha-trifluoromethyl beta-amino acids, and beta-trifluoromethyl beta-amino acids).