The Complex and Diversified Mitochondrial Gene Pool of Berber Populations

被引:61
作者
Coudray, C. [1 ]
Olivieri, A. [2 ]
Achilli, A. [2 ,3 ]
Pala, M. [2 ]
Melhaoui, M. [4 ]
Cherkaoui, M. [5 ]
El-Chennawi, F. [6 ]
Kossmann, M. [7 ]
Torroni, A. [2 ]
Dugoujon, J. M. [1 ]
机构
[1] Univ Toulouse 3, CNRS, Lab Anthropobiol, FRE2960, F-31073 Toulouse, France
[2] Univ Pavia, Dipartimento Genet & Microbiol, I-27100 Pavia, Italy
[3] Univ Perugia, Dipartimento Biol Cellulare & Ambientale, I-06100 Perugia, Italy
[4] Univ Mohammed 1, Fac Sci Oujda, Oujda, Morocco
[5] Univ Cadi Ayyad, Lab Ecol Humaine, Marrakech, Morocco
[6] Univ Mansoura, Fac Med, Mansoura, Egypt
[7] Leiden Univ, Dept Languages & Cultures Africa, Leiden, Netherlands
关键词
Berbers; mtDNA; north african settlement; morocco; Egypt; CONTROL-REGION SEQUENCES; ATLANTIC SLAVE-TRADE; MTDNA HAPLOGROUP-H; NORTH-AFRICA; NEAR-EASTERN; DNA VARIATION; Y-CHROMOSOME; EUROPE; WEST; PHYLOGEOGRAPHY;
D O I
10.1111/j.1469-1809.2008.00493.x
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The mitochondrial DNA variation of 295 Berber-speakers from Morocco (Asni, Bouhria and Figuig) and the Egyptian oasis of Siwa was evaluated by sequencing a portion of the control region (including HVS-I and part of HVS-II) and surveying haplogroup-specific coding region markers. Our findings show that the Berber mitochondrial pool is characterized by an overall high frequency of Western Eurasian haplogroups, a somehow lower frequency of sub-Saharan L lineages, and a significant (but differential) presence of North African haplogroups U6 and M1, thus occupying an intermediate position between European and sub-Saharan populations in PCA analysis. A clear and significant genetic differentiation between the Berbers from Maghreb and Egyptian Berbers was also observed. The first are related to European populations as shown by haplogroup H1 and V frequencies, whereas the latter share more affinities with East African and Nile Valley populations as indicated by the high frequency of M1 and the presence of L0a1, L3i, L4*, and L4b2 lineages. Moreover, haplogroup U6 was not observed in Siwa. We conclude that the origins and maternal diversity of Berber populations are old and complex, and these communities bear genetic characteristics resulting from various events of gene flow with surrounding and migrating populations.
引用
收藏
页码:196 / 214
页数:19
相关论文
共 78 条
[1]   Mitochondrial DNA structure in the Arabian Peninsula [J].
Abu-Amero, Khaled K. ;
Larruga, Jose M. ;
Cabrera, Vicente M. ;
Gonzalez, Ana M. .
BMC EVOLUTIONARY BIOLOGY, 2008, 8 (1)
[2]   The molecular dissection of mtDNA haplogroup H confirms that the Franco-Cantabrian glacial refuge was a major source for the European gene pool [J].
Achilli, A ;
Rengo, C ;
Magri, C ;
Battaglia, V ;
Olivieri, A ;
Scozzari, R ;
Cruciani, F ;
Zeviani, M ;
Briem, E ;
Carelli, V ;
Moral, P ;
Dugoujon, JM ;
Roostalu, U ;
Loogväli, EL ;
Kivisild, T ;
Bandelt, HJ ;
Richards, M ;
Villems, R ;
Santachiara-Benerecetti, AS ;
Semino, O ;
Torroni, A .
AMERICAN JOURNAL OF HUMAN GENETICS, 2004, 75 (05) :910-918
[3]   Saami and Berbers - An unexpected mitochondrial DNA link [J].
Achilli, A ;
Rengo, C ;
Battaglia, V ;
Pala, M ;
Olivieri, A ;
Fornarino, S ;
Magri, C ;
Scozzari, R ;
Babudri, N ;
Santachiara-Benerecetti, AS ;
Bandelt, HJ ;
Semino, O ;
Torroni, A .
AMERICAN JOURNAL OF HUMAN GENETICS, 2005, 76 (05) :883-886
[4]   Mitochondrial DNA variation of modern Tuscans supports the near eastern origin of Etruscans [J].
Achilli, Alessandro ;
Olivieri, Anna ;
Pala, Maria ;
Metspalu, Ene ;
Fornarino, Simona ;
Battaglia, Vincenza ;
Accetturo, Matteo ;
Kutuev, Ildus ;
Khusnutdinova, Elsa ;
Pennarun, Erwan ;
Cerutti, Nicoletta ;
Di Gaetano, Cornelia ;
Crobu, Francesca ;
Palli, Domenico ;
Matullo, Giuseppe ;
Santachiara-Benerecetti, A. Silvana ;
Cavalli-Sforza, L. Luca ;
Semino, Ornella ;
Villems, Richard ;
Bandelt, Hans-Juergen ;
Piazza, Alberto ;
Torroni, Antonio .
AMERICAN JOURNAL OF HUMAN GENETICS, 2007, 80 (04) :759-768
[5]  
Alvarez J. Carlos, 2007, Legal Medicine, V9, P293, DOI 10.1016/j.legalmed.2007.05.005
[6]  
AMMERMAN A, 1973, EXPLANATION CULTURE, P348
[7]   SEQUENCE AND ORGANIZATION OF THE HUMAN MITOCHONDRIAL GENOME [J].
ANDERSON, S ;
BANKIER, AT ;
BARRELL, BG ;
DEBRUIJN, MHL ;
COULSON, AR ;
DROUIN, J ;
EPERON, IC ;
NIERLICH, DP ;
ROE, BA ;
SANGER, F ;
SCHREIER, PH ;
SMITH, AJH ;
STADEN, R ;
YOUNG, IG .
NATURE, 1981, 290 (5806) :457-465
[8]   Reanalysis and revision of the Cambridge reference sequence for human mitochondrial DNA [J].
Andrews, RM ;
Kubacka, I ;
Chinnery, PF ;
Lightowlers, RN ;
Turnbull, DM ;
Howell, N .
NATURE GENETICS, 1999, 23 (02) :147-147
[9]  
Aumassip G., 1994, MILIEUX HOMMES TECHN, P9
[10]  
BANDELT HJ, 1995, GENETICS, V141, P743