The secretion of von Willebrand factor from endothelial cells; an increasingly complicated story

被引：113
作者：
Nightingale, T. [1 ]
Cutler, D. [1 ]
机构：
[1] UCL, MRC Lab Mol Cell Biol, London, England
来源：
JOURNAL OF THROMBOSIS AND HAEMOSTASIS | 2013年 / 11卷
基金：
英国医学研究理事会;
关键词：
endothelial cells; exocytosis; hemostasis; Rab GTPase; von Willebrand factor; Weibel-Palade bodies; WEIBEL-PALADE BODIES; MYOSIN-VA; GRANULE EXOCYTOSIS; REGULATED EXOCYTOSIS; MELANOSOME TRANSPORT; VONWILLEBRAND-FACTOR; COMPOUND EXOCYTOSIS; INSULIN GRANULES; FACTOR MULTIMERS; PLASMA-MEMBRANE;
D O I：
10.1111/jth.12225
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
von Willebrand factor (VWF) plays key roles in both primary and secondary hemostasis by capturing platelets and chaperoning clotting factorVIII, respectively. It is stored within the Weibel-Palade bodies (WPBs) of endothelial cells as a highly prothrombotic protein, and its release is thus necessarily under tight control. Regulating the secretion of VWF involves multiple layers of cellular machinery that act together at different stages, leading to the exocytic fusion of WPBs with the plasma membrane and the consequent release of VWF. This review aims to provide a snapshot of the current understanding of those components, in particular the members of the Rab family, acting in the increasingly complex story of VWF secretion.
引用
收藏
页码：192 / 201
页数：10
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