An efficient synthesis of 4,6-dihydrospiro[azepino[4,3,2-cd]indole-3,3′-indoline]-2′,5(1H)-diones via multi-component reaction

被引：17
作者：
Zou, Bin [1 ]
Chen, Chun [1 ]
Leong, Seh Yong [1 ]
Ding, Mei [1 ]
Smith, Paul W. [1 ]
机构：
[1] Novartis Inst Trop Dis, Singapore 138670, Singapore
来源：
TETRAHEDRON | 2014年 / 70卷 / 03期
关键词：
Spiroazepinoindolone/spirooxindole; Isatin; Indolamine; Meldrum's acid; Multi-component reaction; ONE-POT SYNTHESIS; ENANTIOSELECTIVE SYNTHESIS; SPIROOXINDOLES; SPIROINDOLONES; HETEROCYCLES; DERIVATIVES; INHIBITORS; OXINDOLES; ISATINS; WATER;
D O I：
10.1016/j.tet.2013.12.010
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A facile and efficient one-pot three-component synthesis of spiroazepinoindolones has been developed. Using DMF as solvent without any additional acid or metal catalysts, the three-component reaction of readily available isatins, indolamines, and Meldrum's acid affords a new class of spiroheterocycles in moderate yield. (C) 2013 Published by Elsevier Ltd.
引用
收藏
页码：578 / 582
页数：5
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