Modeling gut-brain interactions in zebrafish

被引：24

作者：

de Abreu, Murilo S. ^{[1
,2
]}

Giacomini, Ana C. V. V. ^{[1
,3
]}

Sysoev, Maksim ^{[4
,10
]}

Demin, Konstantin A. ^{[8
,9
]}

Alekseeva, Polina A. ^{[9
]}

Spagnoli, Sean T. ^{[11
]}

Kalueff, Allan V. ^{[5
,6
,7
,8
,9
,10
]}

机构：

[1] Univ Passo Fundo, Biosci Inst, Passo Fundo, RS, Brazil

[2] Int Zebrafish Neurosci Res Consortium ZNRC, Slidell, LA USA

[3] Univ Passo Fundo, Postgrad Program Environm Sci, Passo Fundo, Brazil

[4] Inst Expt Med, Dept Mol Microbiol, St Petersburg, Russia

[5] Southwest Univ, Sch Pharm, Chongqing, Peoples R China

[6] Sci Res Inst Physiol & Basic Med, Novosibirsk, Russia

[7] Ural Fed Univ, Ekaterinburg, Russia

[8] St Petersburg State Univ, Inst Translat Biomed, St Petersburg, Russia

[9] Minist Healthcare Russian Federat, Inst Expt Med, Almazov Natl Med Res Ctr, St Petersburg, Russia

[10] Minist Healthcare Russian Federat, Granov Russian Natl Res Ctr Radiol & Surg Technol, St Petersburg, Russia

[11] Carlson Coll Vet Med, Oregon Vet Diagnost Lab, Corvallis, OR USA

来源：

BRAIN RESEARCH BULLETIN | 2019年 / 148卷

基金：

俄罗斯基础研究基金会;

关键词：

Gut microbiota; CNS; Immunology; Behavior; The endocrine system; INTESTINAL MICROBIOTA; NEUROSCIENCE RESEARCH; IMMUNE-RESPONSES; BEHAVIOR; SYSTEM; EXPOSURE; STRESS; ADULT; DISORDERS; MICE;

D O I：

10.1016/j.brainresbull.2019.03.003

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Mounting clinical and experimental evidence suggests the gut-brain interplay as a novel important paradigm in translational neuroscience, including the critical role for gut microbiota in modulating brain development and behavior, as well as neuroimmune and neuroendocrine responses. Animal models are an indispensable tool in studying the central nervous system (CNS) disorders and their mechanisms. Recently, the zebrafish (Danio rerio) has become a powerful new model organism in neuroscience, including studying the gut-brain axis. Here, we discuss zebrafish models of gut-brain interplay, endocrine and toxicological effects of zebrafish microbiota, and their impact on neuroimmune and behavioral processes. We particularly emphasize the growing utility of zebrafish models in gut-brain research, as they foster future discoveries of new interconnections between these systems.

引用

页码：55 / 62

页数：8

共 122 条

[1]

[Anonymous], 2009, ZEBRAFISH MODEL SCHI

[2] Host-bacterial mutualism in the human intestine [J].

Bäckhed, F ;

Ley, RE ;

Sonnenburg, JL ;

Peterson, DA ;

Gordon, JI .

SCIENCE, 2005, 307 (5717) :1915-1920

[3] Distinct signals from the microbiota promote different aspects of zebrafish gut differentiation [J].

Bates, Jennifer M. ;

Mittge, Erika ;

Kuhlman, Julie ;

Baden, Katrina N. ;

Cheesman, Sarah E. ;

Guillemin, Karen .

DEVELOPMENTAL BIOLOGY, 2006, 297 (02) :374-386

[4] The Intestinal Microbiota Affect Central Levels of Brain-Derived Neurotropic Factor and Behavior in Mice [J].

Bercik, Premysl ;

Denou, Emmanuel ;

Collins, Josh ;

Jackson, Wendy ;

Lu, Jun ;

Jury, Jennifer ;

Deng, Yikang ;

Blennerhassett, Patricia ;

Macri, Joseph ;

McCoy, Kathy D. ;

Verdu, Elena F. ;

Collins, Stephen M. .

GASTROENTEROLOGY, 2011, 141 (02) :599-U701

[5] Probiotic modulation of the microbiota-gut-brain axis and behaviour in zebrafish [J].

Borrelli, Luca ;

Aceto, Serena ;

Agnisola, Claudio ;

De Paolo, Sofia ;

Dipineto, Ludovico ;

Stilling, Roman M. ;

Dinan, Timothy G. ;

Cryan, John F. ;

Menna, Lucia F. ;

Fioretti, Alessandro .

SCIENTIFIC REPORTS, 2016, 6

[6] The zebrafish as a model to study intestinal inflammation [J].

Brugman, Sylvia .

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2016, 64 :82-92

[7]

Carabotti M, 2015, ANN GASTROENTEROL, V28, P203

[8] Acute exposure to PBDEs at an environmentally realistic concentration causes abrupt changes in the gut microbiota and host health of zebrafish [J].

Chen, Lianguo ;

Hu, Chenyan ;

Lai, Nelson Lok-Shun ;

Zhang, Weipeng ;

Hua, Jianghuan ;

Lam, Paul K. S. ;

Lam, James C. W. ;

Zhou, Bingsheng .

ENVIRONMENTAL POLLUTION, 2018, 240 :17-26

[9] Bacteria activate sensory neurons that modulate pain and inflammation [J].

Chiu, Isaac M. ;

Heesters, Balthasar A. ;

Ghasemlou, Nader ;

Von Hehn, Christian A. ;

Zhao, Fan ;

Tran, Johnathan ;

Wainger, Brian ;

Strominger, Amanda ;

Muralidharan, Sriya ;

Horswill, Alexander R. ;

Wardenburg, Juliane Bubeck ;

Hwang, Sun Wook ;

Carroll, Michael C. ;

Woolf, Clifford J. .

NATURE, 2013, 501 (7465) :52-+

[10] Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour [J].

Cryan, John F. ;

Dinan, Timothy G. .

NATURE REVIEWS NEUROSCIENCE, 2012, 13 (10) :701-712

← 1 2 3 4 5 6 7 8 9 10 →