Engagement of the B lymphocyte antigen receptor induces presentation of intrinsic immunoglobulin peptides on major histocompatibility complex class II molecules

被引:14
作者
Bartnes, K
Hannestad, K
机构
[1] Department of Immunology, University of Tromsø, School of Medicine, Tromsø
[2] Department of Immunology, University of Tromsø, School of Medicine
关键词
B cell antigen receptor; tumor antigen; idiotype; cryptic determinant; lymphocyte interactions;
D O I
10.1002/eji.1830270512
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
By means of the clonotypic variable region, the immunoglobulin (Ig) is a tumor-specific antigen on B cell neoplasms. We report that engagement of the B cell antigen receptor (BcR) promotes presentation of peptides derived from the B cell's intrinsic Ig to major histocompatibility complex (MHC) class II-restricted T cells. Thus, anti-Ig endowed normal, ex vivo B lymphocytes from H-2(d), Ig constant heavy chain allotype b (IgC(H)(b)) mice with the capacity to stimulate an I-A(d)-restricted T cell clone which recognizes the gamma 2a(b) 435-451 allopeptide. The corresponding self gamma 2a(a) peptide is cryptic and 6000-fold less antigenic than the gamma 2a(b) allopeptide. Even so, the syngeneic B cell lymphoma A20 which expresses surface (s) IgG2a(a), was also recognized by the T cells after BcR ligation. Thus, anti-Ig triggered the disclosure of a cryptic tumor antigen determinant. We propose that autoantigens, by engaging the BcR of self-reactive B cells, induce presentation of intrinsic Ig peptides to which the T helper cell (Th) repertoire is not tolerant. In this way, B cells with anti-self potential may be activated without Th recognition of nominal autoantigen.
引用
收藏
页码:1124 / 1130
页数:7
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