Attenuation of the prepulse inhibition of the acoustic startle response within and between sessions

被引：29

作者：

Quednow, BB ^{[1
]}

Kühn, KU ^{[1
]}

Beckmann, K ^{[1
]}

Westheide, J ^{[1
]}

Maier, W ^{[1
]}

Wagner, M ^{[1
]}

机构：

[1] Univ Bonn, Dept Psychiat, D-53105 Bonn, Germany

来源：

BIOLOGICAL PSYCHOLOGY | 2006年 / 71卷 / 03期

关键词：

prepulse inhibition; habituation; acoustic startle response; sensorimotor gating; electromyography; clinical studies; stability; reliability;

D O I：

10.1016/j.biopsycho.2005.05.001

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

Prepulse inhibition (PPI) and habituation of the acoustic startle response (ASR) are widely used biological markers in the study of psychiatric disorders and have been shown to be homologous across species. Previous studies in humans suggested that PPI is a stable and reliable measure between test sessions, but that PPI decreases within sessions. The purpose of this study was to explore the short- and long-term decrease in PPI as a potential confound in the measurement and interpretation of PPI. We investigated the progression of PPI and habituation of ASR in three test sessions spaced 4 weeks apart in a group of 20 healthy participants. Analysis revealed a significant decrease in the percent PPI within and between the test sessions. Nevertheless, PPI was reliable across three test sessions, indicating that the significant attenuation of PPI over time was a consistent phenomenon. These results suggest that PPI exhibits short- and long-term attenuation. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：256 / 263

页数：8

共 47 条

[1] Repeated testing of prepulse inhibition and habituation of the startle reflex: a study in healthy human controls [J].