Peptide Ligation-Desulfurization Chemistry at Arginine

被引：79

作者：

Malins, Lara R. ^{[1
]}

Cergol, Katie M. ^{[1
]}

Payne, Richard J. ^{[1
]}

机构：

[1] Univ Sydney, Sch Chem, Sydney, NSW 2006, Australia

来源：

CHEMBIOCHEM | 2013年 / 14卷 / 05期

基金：

澳大利亚研究理事会;

关键词：

arginine; desulfurization; glycopeptides; ligation; peptides; NATIVE CHEMICAL LIGATION; KINETICALLY CONTROLLED LIGATION; HUMAN PARATHYROID-HORMONE; PROTEIN-SYNTHESIS; PROLINE LIGATION; ERYTHROPOIETIN; GLYCOPEPTIDES; CYSTEINE; BETA; DESELENIZATION;

D O I：

10.1002/cbic.201300049

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The utility of a new beta-thiol arginine building block in ligation-desulfurization chemistry has been demonstrated through reactions and kinetic studies with a range of peptide thioesters. Application of the method is highlighted by a one-pot, kinetically controlled, rapid ligation to generate a 7 kDa MUC1 glycopeptide.

引用

页码：559 / 563

页数：5

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