To dream the impossible dream: universal influenza vaccination

被引：25

作者：

Yewdell, Jonathan W. ^{[1
]}

机构：

[1] NIAID, Viral Dis Lab, Bethesda, MD 20892 USA

来源：

CURRENT OPINION IN VIROLOGY | 2013年 / 3卷 / 03期

关键词：

VIRUS HEMAGGLUTININ; ANTIGENIC STRUCTURE; ANTIBODY DIVERSITY; IMMUNE-RESPONSE; CELL RESPONSES; NEUTRALIZATION; EPITOPES; VACCINES; SPECIFICITY; RECOGNIZES;

D O I：

10.1016/j.coviro.2013.05.008

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Year in and year out, influenza viruses exact a deadly and expensive toll on humanity. Current vaccines simply do not keep pace with viral immune evasion, providing partial protection, at best, among various age groups. A quantum leap in understanding the basic principles of the adaptive and innate immune responses to influenza viruses offers the opportunity to develop vaccines that forestall, and potentially ultimately defeat, influenza virus antigenic variation.

引用

页码：316 / 321

页数：6

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