Rare sesquiterpenes from the algicolous fungus Drechslera dematioidea

被引：65

作者：

Osterhage, C ^{[1
]}

König, GM ^{[1
]}

Höller, U ^{[1
]}

Wright, AD ^{[1
]}

机构：

[1] Tech Univ Carolo Wilhelmina Braunschweig, Inst Pharmaceut Biol, D-38106 Braunschweig, Germany

来源：

JOURNAL OF NATURAL PRODUCTS | 2002年 / 65卷 / 03期

关键词：

D O I：

10.1021/np010092l

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

From the inner tissue of the marine red alga Liagora viscida the fungus Drechslera dematioidea was isolated. After mass cultivation, the fungus was investigated for its secondary metabolite content, and 10 new sesquiterpenoids [isosativenetriol (1), drechslerines A (2) and B (3), 9-hydroxyhelminthosporol (5), drechslerines C-G (6-10), and sativene epoxide (12)] were isolated. Compounds 8 and 10 exhibited antiplasmodial activity against Plasmodium falciparum. strains K1 and NF54. The known compounds helminthosporol (4), cis-sativenediol (11), isocochlioquinone A (14), isocochlioquinone C (15), and cochlioquinone B (16) were also isolated. All structures were elucidated using spectroscopic methods, mainly 1D and 2D NMR and MS.

引用

页码：306 / 313

页数：8

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