Modeling Neuropsychiatric and Neurodegenerative Diseases with induced Pluripotent Stem Cells

被引：15
|
作者：
LaMarca, Elizabeth A. [1 ,2 ,3 ,4 ]
Powell, Samuel K. [1 ,2 ,3 ,5 ]
Akbarian, Schahram [1 ,2 ,3 ]
Brennand, Kristen J. [1 ,2 ,3 ,6 ]
机构：
[1] Icahn Sch Med Mt Sinai, Dept Neurosci, New York, NY 10029 USA
[2] Icahn Sch Med Mt Sinai, Friedman Brain Inst, New York, NY 10029 USA
[3] Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA
[4] Icahn Sch Med Mt Sinai, Grad Sch Biomed Sci, New York, NY 10029 USA
[5] Icahn Sch Med Mt Sinai, Med Scientist Training Program, New York, NY 10029 USA
[6] Icahn Sch Med Mt Sinai, Dept Genet & Genom, New York, NY 10029 USA
来源：
FRONTIERS IN PEDIATRICS | 2018年 / 6卷
关键词：
induced pluripotent stem cells; schizophrenia; Parkinson's disease; neural induction; neural differentiation; ADULT HUMAN FIBROBLASTS; ALPHA-SYNUCLEIN; FUNCTIONAL-NEURONS; DOPAMINERGIC-NEURONS; DIRECT CONVERSION; IPSC LINE; HUMAN ES; DIRECTED DIFFERENTIATION; NEURAL-DIFFERENTIATION; CORTICAL DEVELOPMENT;
D O I：
10.3389/fped.2018.00082
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Human-induced pluripotent stem cells (hiPSCs) have revolutionized our ability to model neuropsychiatric and neurodegenerative diseases, and recent progress in the field is paving the way for improved therapeutics. In this review, we discuss major advances in generating hiPSC-derived neural cells and cutting-edge techniques that are transforming hiPSC technology, such as three-dimensional "mini-brains" and clustered, regularly interspersed short palindromic repeats (CRISPR)-Cas systems. We examine specific examples of how hiPSC-derived neural cells are being used to uncover the pathophysiology of schizophrenia and Parkinson's disease, and consider the future of this groundbreaking research.
引用
收藏
页数：15
相关论文
共 50 条
  • [21] Modeling Polyglutamine Expansion Diseases with Induced Pluripotent Stem Cells
    Naphade, Swati
    Tshilenge, Kizito-Tshitoko
    Ellerby, Lisa M.
    NEUROTHERAPEUTICS, 2019, 16 (04) : 979 - 998
  • [22] Modeling blood diseases with human induced pluripotent stem cells
    Georgomanoli, Maria
    Papapetrou, Eirini P.
    DISEASE MODELS & MECHANISMS, 2019, 12 (06)
  • [23] Modeling Polyglutamine Expansion Diseases with Induced Pluripotent Stem Cells
    Swati Naphade
    Kizito-Tshitoko Tshilenge
    Lisa M. Ellerby
    Neurotherapeutics, 2019, 16 : 979 - 998
  • [24] Modeling aortic diseases using induced pluripotent stem cells
    Zhu, Kai
    Ma, Wenrui
    Li, Jun
    Zhang, Yu Shrike
    Zhang, Weijia
    Lai, Hao
    Wang, Chunsheng
    STEM CELLS TRANSLATIONAL MEDICINE, 2021, 10 (02) : 190 - 197
  • [25] Induced pluripotent stem cell-based modeling of neurodegenerative diseases: a focus on autophagy
    Jungverdorben, Johannes
    Till, Andreas
    Bruestle, Oliver
    JOURNAL OF MOLECULAR MEDICINE-JMM, 2017, 95 (07): : 705 - 718
  • [26] Induced pluripotent stem cell-based modeling of neurodegenerative diseases: a focus on autophagy
    Johannes Jungverdorben
    Andreas Till
    Oliver Brüstle
    Journal of Molecular Medicine, 2017, 95 : 705 - 718
  • [27] Generation of Induced Pluripotent Stem Cells from Asian Patients with Chronic Neurodegenerative Diseases
    Luo, Yumei
    Fan, Yong
    Chen, Xinjie
    Yu, Bolan
    Yue, Lei
    Wang, Ding
    Li, Qing
    Chen, Yaoyong
    Sun, Xiaofang
    JOURNAL OF REPRODUCTION AND DEVELOPMENT, 2012, 58 (05): : 515 - 521
  • [28] Modeling Human Neurological and Neurodegenerative Diseases: From Induced Pluripotent Stem Cells to Neuronal Differentiation and Its Applications in Neurotrauma
    Bahmad, Hisham
    Hadadeh, Ola
    Chamaa, Farah
    Cheaito, Katia
    Darwish, Batoul
    Makkawi, Ahmad-Kareem
    Abou-Kheir, Wassim
    FRONTIERS IN MOLECULAR NEUROSCIENCE, 2017, 10
  • [29] Human Pluripotent Stem Cells as In Vitro Models of Neurodegenerative Diseases
    Machairaki, Vasiliki
    GENEDIS 2018: GENETICS AND NEURODEGENERATION, 2020, 1195 : 93 - 94
  • [30] Microglia alterations in neurodegenerative diseases and their modeling with human induced pluripotent stem cell and other platforms
    Maria Sabogal-Guaqueta, Angelica
    Marmolejo-Garza, Alejandro
    de Padua, Vitor Passos
    Eggen, Bart
    Boddeke, Erik
    Dolga, Amalia M.
    PROGRESS IN NEUROBIOLOGY, 2020, 190
12345