Modeling Neuropsychiatric and Neurodegenerative Diseases with induced Pluripotent Stem Cells

被引：15
|
作者：
LaMarca, Elizabeth A. [1 ,2 ,3 ,4 ]
Powell, Samuel K. [1 ,2 ,3 ,5 ]
Akbarian, Schahram [1 ,2 ,3 ]
Brennand, Kristen J. [1 ,2 ,3 ,6 ]
机构：
[1] Icahn Sch Med Mt Sinai, Dept Neurosci, New York, NY 10029 USA
[2] Icahn Sch Med Mt Sinai, Friedman Brain Inst, New York, NY 10029 USA
[3] Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA
[4] Icahn Sch Med Mt Sinai, Grad Sch Biomed Sci, New York, NY 10029 USA
[5] Icahn Sch Med Mt Sinai, Med Scientist Training Program, New York, NY 10029 USA
[6] Icahn Sch Med Mt Sinai, Dept Genet & Genom, New York, NY 10029 USA
来源：
FRONTIERS IN PEDIATRICS | 2018年 / 6卷
关键词：
induced pluripotent stem cells; schizophrenia; Parkinson's disease; neural induction; neural differentiation; ADULT HUMAN FIBROBLASTS; ALPHA-SYNUCLEIN; FUNCTIONAL-NEURONS; DOPAMINERGIC-NEURONS; DIRECT CONVERSION; IPSC LINE; HUMAN ES; DIRECTED DIFFERENTIATION; NEURAL-DIFFERENTIATION; CORTICAL DEVELOPMENT;
D O I：
10.3389/fped.2018.00082
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Human-induced pluripotent stem cells (hiPSCs) have revolutionized our ability to model neuropsychiatric and neurodegenerative diseases, and recent progress in the field is paving the way for improved therapeutics. In this review, we discuss major advances in generating hiPSC-derived neural cells and cutting-edge techniques that are transforming hiPSC technology, such as three-dimensional "mini-brains" and clustered, regularly interspersed short palindromic repeats (CRISPR)-Cas systems. We examine specific examples of how hiPSC-derived neural cells are being used to uncover the pathophysiology of schizophrenia and Parkinson's disease, and consider the future of this groundbreaking research.
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收藏
页数：15
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