Differentially Addressable Cavities within Metal-Organic Cage-Cross-Linked Polymeric Hydrogels

被引：147

作者：

Foster, Jonathan A. ^{[1
]}

Parker, Richard M. ^{[1
]}

Belenguer, Ana M. ^{[1
]}

Kishi, Norifumi ^{[2
]}

Sutton, Sam ^{[1
]}

Abell, Chris ^{[1
]}

Nitschke, Jonathan R. ^{[1
]}

机构：

[1] Univ Cambridge, Cambridge CB2 1EW, England

[2] Tokyo Inst Technol, Chem Resources Lab, Midori Ku, Yokohama, Kanagawa 2268502, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2015年 / 137卷 / 30期

基金：

英国工程与自然科学研究理事会; 欧洲研究理事会;

关键词：

DRUG-DELIVERY SYSTEMS; SUPRAMOLECULAR GELS; CONTROLLED-RELEASE; STIMULI RESPONSIVENESS; GUEST INTERACTIONS; COORDINATION; DESIGN; MICROFLUIDICS; CHEMISTRY; ENCAPSULATION;

D O I：

10.1021/jacs.5b05507

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Here we report a new class of hydrogels formed by polymers that are cross-linked through subcomponent self-assembled metal organic cages. Selective encapsulation of guest molecules with in the cages. creates two distinct internal phases within the hydrogel, which allows for contrasting release profiles of related, molecules depending on their aptitude, for encapsulation within the cages. The hydrogels were fabricated into microparticles via a droplet-based microfluidic approach and proved responsive to a variety, of stimuli, including acid and competing amine or aldehyde subcomponents, allowing for the triggered release of cargo.

引用

收藏

页码：9722 / 9729

页数：8

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