Allylation of aldehydes and imines:: Promoted by reuseable polymer-supported sulfonamide of N-glycine

被引：57

作者：

Li, GL ^{[1
]}

Zhao, G ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, Lab Modern Synth Organ Chem, Shanghai 200032, Peoples R China

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 04期

关键词：

D O I：

10.1021/ol0528235

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A allylation of aldehydes and imines (generated in situ from aldehydes and amines) with allyltributyltin promoted by recoverable and reusable the polymer-supported sulfonamide of N-glycine has been developed. Good to high yields were obtained in various cases. Most of the SnBu3 residue can be recovered as Bu3SnCl. Highly stereoselective synthesis of N-Boc-(2S,3S)-3-hydroxy-2-phenylpiperidine 7 was achieved by using the P4a-mediated allylation of Boc-L-phenylglycinal as a key step.

引用

页码：633 / 636

页数：4

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