Myc's broad reach

被引：750

作者：

Eilers, Martin ^{[2
]}

Eisenman, Robert N. ^{[1
]}

机构：

[1] Fred Hutchinson Canc Res Ctr, Div Basic Sci, Seattle, WA 98109 USA

[2] Inst Mol Biol & Tumor Res IMT, D-35033 Marburg, Germany

来源：

GENES & DEVELOPMENT | 2008年 / 22卷 / 20期

关键词：

Myc; cancer; growth; stem cells; target genes; transcription;

D O I：

10.1101/gad.1712408

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The role of the myc gene family in the biology of normal and cancer cells has been intensively studied since the early 1980s. myc genes, responding to diverse external and internal signals, express transcription factors (c-, N-, and L- Myc) that heterodimerize with Max, bind DNA, and modulate expression of a specific set of target genes. Over the last few years, expression profiling, genomic binding studies, and genetic analyses in mammals and Drosophila have led to an expanded view of Myc function. This review is focused on two major aspects of Myc: the nature of the genes and pathways that are targeted by Myc, and the role of Myc in stem cell and cancer biology.

引用

页码：2755 / 2766

页数：12

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