OSCAR Study lessons - "EpidemiOlogy and treatment of high-riSk patients in real-world ClinicAl pRactice, 2005-2006"

Aim. To present the results of OSCAR-2006 therapeutic program; to discuss lipid-lowering therapy effectiveness ill real-world clinical practice. Material and methods. In total, the Study included 7098 patients, with more than 50% suffering from verified (86,8%) coronary heart disease (CHD). The program was educational: patients did not receive free simvastatin or atorvastatin for 8 weeks. but were persuaded to take the medications Purchased by themselves. Results. After 8-week statin therapy (atorvastatin), the levels of total cholesterol (TCH) were reduced by 22.7% low-density CH (LDL-CH) - by 26,7%, and triglycerides - by 24,0%. Treatment effectiveness (achieving target LDL-CH levels < 2,6 mmol/l) increased from 4,3% to 17,0%. Lipid and blood pressure reduction resulted in total cardiovascular risk decrease by 33%. OSCAR Study results are also promising in regard to statin safety. During the study. only 195 (2,7%) adverse events were registered. Conclusion. In a large-scale, real-world clinical practice study. the perspectives of risk factor control by using medications improving life prognosis were demonstrated.