Biological systems: from water radiolysis to carbon ion radiotherapy

被引：2

作者：

Beuve, Michael ^{[1
]}

Moreau, Jean-Michel ^{[2
]}

Rodriguez, Claire ^{[3
]}

Testa, Etienne ^{[1
]}

机构：

[1] Univ Lyon 1, CNRS, IN2P3, IPNL,UMR 5822, F-69622 Villeurbanne, France

[2] Univ Lyon 1, LIRIS, F-69622 Villeurbanne, France

[3] Univ Lyon 1, LRCM, F-69622 Villeurbanne, France

来源：

CIRIL, 30 YEARS OF INTERDISCIPLINARY RESEARCH AT GANIL | 2015年 / 629卷

关键词：

MICRODOSIMETRIC-KINETIC-MODEL; LOCAL EFFECT MODEL; HIGH-LET TRACKS; HEAVY-ION; CELL INACTIVATION; MULTIPLE IONIZATION; ALPHA-PARTICLES; DNA; IRRADIATION; RADIATION;

D O I：

10.1088/1742-6596/629/1/012004

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

Hadron therapy is an innovative cancer treatment method based on the acceleration of light ions at high energy. In addition to their interesting profile of dose deposition, which ensures accurate targeting of localized tumors, carbon ions offer biological properties that lead to an efficient treatment for radio- and chemo-resistant tumors and to provide a boost for tumors in hypoxia. This paper is a short review of the progress in theoretical, experimental, fundamental and applied research, aiming at understanding the origin of the biological benefits of light ions better. As a limit of such a vast and multidisciplinary domain, this review adopts the point of view of the physicists, leaning on results obtained in connection with CIMAP's IRRABAT platform.

引用

页数：11

共 48 条

[1]

AIKENS J, 1991, J BIOL CHEM, V266, P15091

[2]

[Anonymous], 2005, Radicaux libres et stress oxydant: aspects biologiques et pathologiques: Editions Tec doc

[3] Direct time-resolved measurement of radical species formed in water by heavy ions irradiation [J].

Baldacchino, G ;

Bouffard, S ;

Balanzat, E ;

Gardès-Albert, M ;

Abedinzadeh, Z ;

Jore, D ;

Deycard, S ;

Hickel, B .

NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS, 1998, 146 (1-4) :528-532

[4] OXYGEN AS A PRODUCT OF WATER RADIOLYSIS IN HIGH-LET TRACKS .2. RADIOBIOLOGICAL IMPLICATIONS [J].

BAVERSTOCK, KF ;

BURNS, WG .

RADIATION RESEARCH, 1981, 86 (01) :20-33

[5] RADACK, a stochastic simulation of hydroxyl radical attack to DNA. [J].

Begusova, M ;

Spotheim-Maurizot, M ;

Sy, D ;

Michalik, V ;

Charlier, M .

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2001, 19 (01) :141-+

[6] Formalization and Theoretical Analysis of the Local Effect Model [J].

Beuve, M. .

RADIATION RESEARCH, 2009, 172 (03) :394-402

[7] Statistical effects of dose deposition in track-structure modelling of radiobiology efficiency [J].

Beuve, M. ;

Colliaux, A. ;

Dabli, D. ;

Dauvergne, D. ;

Gervais, B. ;

Montarou, G. ;

Testa, E. .

NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS, 2009, 267 (06) :983-988

[8] Radiobiologic parameters and local effect model predictions for head-and-neck squamous cell carcinomas exposed to high linear energy transfer ions [J].

Beuve, Michael ;

Alphonse, Gersende ;

Maalouf, Mira ;

Colliaux, Anthony ;

Battiston-Montagne, Priscilla ;

Jalade, Patrice ;

Balanzat, Emmanuel ;

Demeyer, Albert ;

Bajard, Marcel ;

Rodriguez-Lafrasse, Claire .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2008, 71 (02) :635-642

[9] DNA core ionization and cell inactivation [J].

Boissiere, Arnaud ;

Champion, Christophe ;

Touati, Alain ;

du Penhoat, Marie-Anne Herve ;

Sabatier, Laure ;

Chatterjee, Aloke ;

Chetioui, Annie .

RADIATION RESEARCH, 2007, 167 (04) :493-500

[10]

BURNS WG, 1981, RADIAT RES, V86, P1, DOI 10.2307/3575595

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