Preparation of a novel bone wax with modified tricalcium silicate cement and BGs

被引:12
作者
Cao, Weijing [1 ]
Zong, Shouyang [2 ]
Zhang, Yin [1 ,4 ]
Qiu, Fan [3 ,5 ]
Tang, Jun [1 ]
Wu, Zhenning [1 ]
Luan, Jiapan [1 ]
机构
[1] Nanjing Tech Univ, Coll Mat Sci & Engn, Nanjing 210009, Peoples R China
[2] Peoples Hosp Jinhu Country, Dept Clin Lab, Huaian, Peoples R China
[3] Nanjing Med Univ, Nanjing Hosp 1, Dept Nucl Med, Nanjing 210006, Jiangsu, Peoples R China
[4] Nanjing Haoqi Adv Mat Co Ltd, Nanjing 211300, Jiangsu, Peoples R China
[5] Nanjing Univ, Coll Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210093, Jiangsu, Peoples R China
来源
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2019年 / 99卷
关键词
Bone wax; A-V-C3S; Degradation; Antibacterial; Biocompatible; CALCIUM; PROLIFERATION; BIOACTIVITY; ADMIXTURES;
D O I
10.1016/j.msec.2019.02.049
中图分类号
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号
0805 ; 080501 ; 080502 ;
摘要
Amino-grafted and vaterite-contained tricalcium silicate cement (A-V-C3S) was composited with 58S bioglass/chitosan/carboxy methyl cellulose (BG/CS/CMC, referred as BGs) to surmount the non-absorbability and infection problems of traditional bone wax. Its material, bioactive, biocompatible and antibacterial properties were systematically characterized. The results revealed that A-V-C3S/BGs possessed self-setting, injectable, mechanical and degradable abilities. A-V-C3S/BGs (1:1 g/g) was optimum owing to its higher compressive strength (9.91 MPa) and lower pH value (7.6 to 8.1) in the test groups. In vitro immersion experiment demonstrated that A-V-C3S/BGs had good hydroxyapatite formation ability, and its excellent cell adhesion, low cytotoxicity and superior cell proliferation were verified by mouse embryonic osteoblast precursor cells in cell tests. Compared with A-V-C3S, antibacterial experiment illustrated the significantly enhanced antibacterial property of A-V-C3S/BGs to Staphylococcus aureus and Escherichia coli.
引用
收藏
页码:979 / 985
页数:7
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