Changes in the Myocardial Interstitium and Contribution to the Progression of Heart Failure

被引：42
作者：
Eckhouse, Shaina R. [3 ]
Spinale, Francis G. [1 ,2 ]
机构：
[1] Univ S Carolina, Sch Med, CVCTRC, Dept Cell Biol & Anat, Columbia, SC 29208 USA
[2] Med Univ S Carolina, Dept Surg, Charleston, SC 29425 USA
[3] Med Univ S Carolina, Div Cardiothorac Surg, Dept Surg, Charleston, SC 29425 USA
来源：
HEART FAILURE CLINICS | 2012年 / 8卷 / 01期
关键词：
Interstitium; Extracellular matrix; Heart failure; Pressure overload hypertrophy; Dilated cardiomyopathy; Myocardial infarction; GROWTH-FACTOR-BETA; LEFT-VENTRICULAR HYPERTROPHY; ASSIST DEVICE SUPPORT; AORTIC-VALVE DISEASE; IDIOPATHIC DILATED CARDIOMYOPATHY; COLLAGEN CROSS-LINKING; FAILING HUMAN HEART; MATRIX METALLOPROTEINASES; EXTRACELLULAR-MATRIX; TISSUE INHIBITOR;
D O I：
10.1016/j.hfc.2011.08.012
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The myocardial interstitium is highly organized and orchestrated, whereby small disruptions in composition, spatial relationships, or content lead to altered myocardial systolic and/or diastolic performance. These changes in extracellular matrix structure and function are important in the progression to heart failure in pressure overload hypertrophy, dilated cardiomyopathy, and ischemic heart disease. The myocardial interstitium is not a passive entity, but rather a complex and dynamic microenvironment that represents an important structural and signaling system within the myocardium.
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页码：7 / +
页数：15
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